Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Six little fish in the sea can be seen, but can you find the fish with scales that are green? Gentle rhyming text combines with a fun spotting activity to present early concepts in a fun new way. Can

Let's say hello to the animals at the zoo. One is tall and spotty, can you see who? Gentle rhyming text combines with a fun spotting activity to present early concepts in a fun new way. Explore famili

New in the Little People, Big Dreams series, this inspiring and informative little biography follows the colourful life of iconic actress Audrey Hepburn, from her early life during World War Two, to b

★ 前華爾街量化分析師揭露：演算法如何操控你的未來★ 大數據黑暗面全面曝光：看不見的歧視與不公平我們以為世界正變得更公平——由機器取代人類做決策，似乎能消除偏見。但真相，可能正好相反。在這個「演算法主宰」的時代，你能否錄取學校、拿到工作、申請貸款，甚至保險費率高低，都悄悄被一套看不見的數學模型決定。這些系統看似客觀，卻無法被檢驗，也無從質疑，一旦出錯，影響卻會層層放大。數學家暨資料科學家凱西．歐尼爾，以親身經驗揭開大數據的陰暗面：這些模型不只沒有消除不平等，反而強化既有的階級與歧視，讓弱勢更難翻身。本書如同一場警醒之旅，帶你看見科技背後不為人知的權力運作。NEW YORK TIMES BESTSELLER • A former Wall Street quant sounds the alarm on Big Data and the mathematical models that threaten to rip apart our social fabric—with a new afterword“A manual for the twenty-first-century citizen . . . relevant and urgent.”—Financial TimesNATIONAL BOOK AWARD LONGLIST • NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The New York Times Book Review • The Boston Globe • Wired • Fortune • Kirkus Reviews • The Guardian • Nature • On PointWe live in the age of the algorithm. Increasingly, the decisions that affect our lives—where we go to school, whether we can get a job or a loan, how much we pay for health insurance—are being made not by humans, but by machines. In theory, this should lead t

The wacky robots from the award-winning StoryBots apps, videos, and Netflix show now star in their own early readers. This one is about everyone’s favorite dinosaur!Fans of the StoryBots will recogniz

#1 The Crooked Sixpence (THE UNCOMMONERS)#2 The Smoking Hourglass (THE UNCOMMONERS)#3 Jennifer Bell, Karl James Mountford (THE UNCOMMONERS)★ 英倫奇幻冒險《The Uncommoners》三部曲★ 魔法城市 × 神祕交易市場 × 世界級奇幻冒險★ 從倫敦地下城市到紐約神祕市場，魔法世界全面擴張★ 《哈利波特》《善惡學院》讀者必讀的奇幻系列在倫敦地下，藏著一座神祕城市——Lundinor。這裡的世界與眾不同：普通物品可能擁有不可思議的魔法力量，各式奇妙物件在祕密市場流通。當艾薇與哥哥賽布意外闖入這個世界，他們被捲入一場危險冒險，必須解開家族祕密、尋找失蹤的人，並阻止黑暗勢力奪取強大的魔法物品。《The Uncommoners》三部曲帶來充滿想像力的奇幻冒險。*]:pointer-events-auto scroll-mt-[calc(var(--header-height)+min(200px,max(70px,20svh)))]" data-turn="assistant" data-scroll-anchor="true" data-testid="conversation-turn-16" data-turn-id="request-WEB:62142b30-ffda-462a-bca8-86a529fefff7-78">Hidden beneath the streets of London lies the extraordinary city of Lundinor — a secret world where ordinary objects possess extraordinary powers.In this hidden city, mysterious traders deal in magical items: enchanted feathers that write messages, coins with strange abilities, and countless uncommon objects whose powers are yet to be discovered.When Ivy S

Chosen as one of The New York Times Best Illustrated Children's Books 2016 Little Red Riding Hood meets a wolf on her way through the woods to visit her sick grandmother. The wolf is hungry, and Red R

This book explores the development of late 19th century study societies in China against the context of the decline of the imperial Qing government and its control on ideological production, widesprea

Margaret Hamilton loved numbers as a young girl. She knew how many miles it was to the moon (and how many back). She loved studying algebra and geometry and calculus and using math to solve problems i

From TV Star to the dorkiest princess around, life is anything but dull for Nikki Maxwell! This dork-tastic bind-up features TV STAR and ONCE UPON A DORK as Nikki goes from being the star of her own r

This early learning play sets consists of a board book with bright photographs and chunky press out puzzle pieces in a plastic pocket. Designed to develop a young child's vocabulary and matching skill

“A brisk historical tour of the marketing and selling of the small principality of Monaco and its famous city…A well-researched, dramatic rags-to-riches urban tale” (Kirkus Reviews) of Monte Carlo’s r

The third edition of the book introduces the fundamentals of the finite element method through simple examples and an applications-oriented approach using the latest computational tools. Using the tra

●一本學通！當代量化研究的主要統計方法學典範：結構方程模型（SEM）。●扎實的統計方法說明，並提供不同情境的實證分析範例。●圖片詳解操作流程，無痛學習地表最強統計軟體──Stata。●本書範例檔案建議使用Stata 13或更新版本執行。◎隨書附贈資料檔光碟 結構方程模型（structural equation modeling, SEM）是一種結合路徑分析（path analysis

本書提供學生在研究實物上珍貴的紙引，包含分析資料與操作電腦套裝軟體。內容務實且希望能聚焦在研究分析者真正的需求上，故部分章節除了彙整實用基礎統計學外，也指導如何有效呈現數據。此書著重於協助您針對資料選擇適合的統計檢定方法，還要利用統計軟體進行分析，並將研究結果做最佳的解讀詮釋；軟體包括SPSS、Minitab、Excel和R，其中R軟體僅於此最新版中介紹。我們盡量以清楚易懂的文字介紹統計，而特殊專

This stylish, highly illustrated, interactive book is perfect for sharing with little children, and introduces the science of the senses using a friendly lift-the-flap format. Text is kept to a minimu

Many books explain what is known about the universe. This book investigates what cannot be known. Rather than exploring the amazing facts that science, mathematics, and r

In the sixth book in the best-selling Dragon Masters series, the prime Dragon Stone is in trouble!Pick a book. Grow a Reader!This series is part of Scholastic's early chapter book line, Branches, aimed at newly independent readers. With easy-to-read text, high-interest content, fast-paced plots, and illustrations on every page, these books will boost reading confidence and stamina. Branches books help readers grow!In book #6, the Dragon Masters have to save the prime Dragon Stone -- or they will lose their connections to their dragons forever! The Dragon Masters travel to the Land of Pyramids in search of the secret Pyramid of the Seven Dragons. There are several puzzles they'll need to solve in order to reach the hidden stone. Will the Dragon Masters find the prime Dragon Stone in time?

First written in response to a JACT survey of over 100 schools, this textbook has become a standard resource for students throughout the UK and for readers across the world who are looking for a clear and thorough introduction to the language of the ancient Greeks. Now revised throughout and enhanced by colour artwork and text features, this revised edition will support the new OCR specification for Classical Greek (first teaching 2016).Written by a long-time school teacher and examiner, this two-part course is based on experience of what pupils find difficult, concentrating on the essentials and on the understanding of principles in both accidence and syntax: minor irregularities are postponed and subordinated so that the need for rote learning is reduced. It aims to be user-friendly, but also to give pupils a firm foundation for further study. Part 1 covers the basics and is self-contained, with its own reference section. It covers the main declensions, a range of active tenses and a

ABC Animal is an entertaining early learning book with creative and captivating illustrations. Whimsical phrases and bright illustrations will help your preschooler learn the alphabet, names of animal

Since the publication of the first edition in 2011, new security threats have come to the forefront. Among these, we have heard about terrorist weapons/delivery methods becoming increasingly sophistic

The five gently spine-tingling, funny stories in this Level Two I Can Read box set are sure to delight early readers. Titles include: Flat Stanley and the Haunted House Monster School: First Day Fri

Are you using natural remedies to reduce stress or improve your health? With the fully updated and revised Encyclopedia of Herbal Medicine, you can join the ever-increasing numbers that are. Written b

Today, artists are able to create using multiple methods of production―from painting to digital technologies to crowdsourcing―some of which would have been unheard of just a few decades ago. Yet, even

Explore the history of Ellis Island, one of the most recognized landmarks in American history. Kids will learn about its early history as a Mohegan island and rest spot for fishermen through its time

This pocket-sized, practical guide has everything the acrylic artist needs to know about color mixing, from color theory to complementary, warm and cool colors, color tone, using a limited palette, dull and bright colors and local color. There follows an array of essential color mixes using widely available Winsor & Newton colors. Clear, practical and beautifully presented advice.

Claudia and her sister, Janine, may as well be from two different planets. Claudia, who pays more attention to her artwork and The Baby-sitters Club than her homework, feels like she can't compete with her perfect sister. Janine studies nonstop, gets straight As, and even takes college-level courses! But when something unexpected happens to the most beloved person in their family, will the sisters be able to put aside their differences?Raina Telgemeier, using the signature style featured in her acclaimed graphic novelsSmile and Sisters, perfectly captures all the drama and charm of the original novel!

It wasn't easy being a Nintendo fan in the early 90s: the wonderful Super Famicom was released in Europe as the Super Nintendo Entertainment System, but it was hobbled by a bordered, 50Hz image and de

"Discusses the science of gymnastics, using biology, physics and engineering"--

DescriptionThe Wolf and the Seven Children Level 3-3Mother Goat goes out for the day. Her seven children are home. They know not to open the door. But the Wolf has an idea to get in!Early readers will

Big Data（大數據）在這幾年突然開始被掛在行銷廣告、學者研究，甚至上班族的日常工作中，而大數據特性包含三種層面：巨量、即時性及多樣性。早期其實就存在許多透過資料來佐證或者分析預測結果的例子，但伴隨著全球化的網路效應及社群網站的發展，資料的數量已達到一般方式無法負荷的境界，因此有了Big Data這個名詞。 在人人都想談論Big Data的時代，大家都想使用它，但應該如何有效地使用則是一門大學

Level: EYFSSubject: English An engaging Writing activity book to really help boost your child's progress at every stage of their learning! Fully in line with the Early Years Foundation Stage,

Heidi Heckelbeck wants to prove she can make it in the babysitting business, but she’ll need a little magic and a lot of help from her friends!Heidi Heckelbeck is eager to start babysitting, but her mom doesn’t think she’s old enough yet. To prove she’s ready to be responsible, Heidi teams up with Laurel and Bruce to create a spectacular booth—called the “Little Explorers Museum”—for the Brewster Elementary fair. It’s going to be an exciting exhibit of fabulous art projects, nifty science experiments…and babysitting! But when Heidi worries that her babysitting station won’t attract enough visitors, will her Book of Spells help her find a magical solution?With easy-to-read language and illustrations on almost ever page, the Heidi Heckelbeck chapter books are perfect for beginning readers.

Bugis Street was famous (or notorious) for being a haunt of transgender prostitution in the early decades of postcolonial Singapore. Since then the site has been a source of touristic obsession and lo

The Writing Kit series prepares students for a wide variety of English writing tasks using a step-by-step method. There are four books designed for primary school students to develop their writing ski

This heartwarming book encourages positive behavior by using the concept of an invisible bucket to show children how easy and rewarding it is to express kindness, appreciation, and love by "filling bu

‘Deliciously Chocolatey’ features ideas that cater for all chocolate cake lovers with child friendly recipes using exciting ingredients like popping candy and homemade marshmallows, afternoon offering

Learning to read is fun with the Rainbow Magic Fairies! Developed in conjunction with Early Years reading consultants and based on the most up-to-date educational research, the Rainbow Magic Beginner

New York Times bestselling author William R. Forstchen brings a sequel to his hit novelOne Second After. Months before publication, One Second After was cited on the floor of Congress as a book all Americans should read, a book discussed in the corridors of the Pentagon as a truly realistic look at the dangers of EMPs. An EMP is a weapon with the power to destroy the entire United States in a single act of terrorism, in a single second; indeed, it is a weapon that theWall Street Journal warns could shatter America. In the tradition of On the Beach,Fail Safe and Testament, One Second After was a dire warning of what might be our future...and our end. Now,One Year After returns to the small town of Black Mountain, and the man who struggled so hard to rebuild it in the wake of devastation-John Matherson. It is a thrilling follow-up and should delight fans in every way.

本書特色 雲端運算是基於網際網路的運算方式，它通過網際網路為個人使用者或企業使用者提供按需即取的服務。隨著電腦技術的發展，資料的存儲量成倍的增長，Data Mining 技術在“資料海洋、知識荒漠”的背景下應運而生的，並且一經出現就得到各個領域的重視。隨著Data Mining 的逐漸成熟，以Data Mining 為核心的Business Intelligence（BI）已經成為了IT 和其他行