Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

NEW YORK TIMES BESTSELLER - From world-renowned historian and philosopher Yuval Noah Harari, the bestselling author of Sapiens, comes an exciting, illustrated book for middle school readers that looks at the early history of humankind. A New York Times Best Book of the Year"Gripping and thought-provoking." --The New York TimesEven though we'll never outrun a hungry lion or outswim an angry shark, humans are pretty impressive--and we're the most dominant species on the planet. So how exactly did we become "unstoppable"? The answer to that is one of the strangest tales you'll ever hear. And it's a true story! From learning to make fire and using the stars as guides to cooking meals in microwaves and landing on the moon, prepare to uncover the secrets and superpowers of how we evolved from our first appearances on Earth millions of years ago. Acclaimed author Yuval Noah Harari has expertly crafted an extraordinary story of how humans learned to not only survive but also thrive on Earth, c

一、深入淺出的範例教學；二、實務資料的分析解讀；三、豐富有趣的圖表繪製；四、數量充足的測驗習題。本書將部分主題有系統地整理，置於附錄，有助R語言之學習及彩圖之精進。

From BIG BANGS to tiny atoms SCIENCE tells us why things happen. Explore the whys, whats and hows of science and answer all the really BIG questions that curious kids are keen to ask. This playful rhyming book bubbles and bursts with all things scientific, from technology and space to experiments, inventions and the natural world.

It’s fun to be smart! These two illustration-based card decks are packed with early learning questions that promote language development, cognitive growth, and social skills for fifth graders.Loved by kids, teacher approved, and trusted by parents, Brain Quest For Threes question-and-answer cards help children explore and learn about the alphabet, counting, recognizing shapes, comparing and matching, and more! In a set of two decks, Brain Quest For Threes features hundreds of questions to help kids learn exactly what they need to know, when they need to know it.Featuring:Two full-color Q&A decks in a reusable flip-top storage boxA parent guide to help maximize the learning and fun300 questions that set the foundation for pre-school learningWhat’s New?Technology questions: Introduce children to the basics of computers and technologyExpanded social and emotional learning: Explores feelings and interactions with peersUpdated content: Fresh and relevant to today’s familiesBrain Quest d

It’s fun to be smart! These two illustration-based card decks are packed with early learning questions that promote language development, cognitive growth, and social skills for fifth graders.Loved by kids, teacher approved, and trusted by parents, Brain Quest For Twos question-and-answer cards help children explore and talk about daily routines, seasonal activities, and outings as they identify objects, shapes, colors, and more! In a set of two decks, Brain Quest For Twos features hundreds of questions to help kids learn exactly what they need to know, when they need to know it.Featuring:Two full-color Q&A decks in a reusable flip-top storage boxA parent guide to help maximize the learning and funOver 300 questions covering colors, counting, object identification, shapes, and moreWhat’s New?New content: Twenty-two brand-new cards added!Technology questions: Introduce children to the basics of computers and technologyExpanded social and emotional learning: Explores feelings and int

It’s fun to be smart! Packed with early learning questions that promote language development, cognitive growth, and social skills, these illustration-based card decks are the key to making Pre-K fun.Loved by kids, teacher approved, and trusted by parents, Brain Quest Pre-Kindergarten question-and-answer cards help children explore and learn about phonics, word study, counting, matching, sequencing, and more! In a set of two decks, Brain Quest Pre-Kindergarten features hundreds of questions to help kids learn exactly what they need to know, when they need to know it.Featuring:Two full-color Q&A decks in a reusable flip-top storage boxA parent guide to help maximize the learning and fun300 questions that set the foundation for learningWhat’s New?Technology questions: Introduce children to the basics of computers and technologyExpanded social and emotional learning: Explores feelings and interactions with peersUpdated content: Fresh and relevant to today’s familiesBrain Quest decks ar

Discover how space is part of our daily lives with Everyday STEM Science - Space, filled with facts, stories and experiments to try at home!Everyone knows there are planets and stars and space rocks, but how do these, and everything else in space, affect us on Earth? From the beginning of the universe and the origins of the planets, to the latest research and space missions, journey through space and uncover what is really out there . . .Discover how we're made of stars, find out how old you would be if you lived on Mars, and how time travel can happen in space. Plus, meet the explorers, astronomers and scientists whose discoveries have given us this fascinating space knowledge, including Mae Jemison, Stephen Hawking and Cecilia Payne-Gaposchkin. Readers can also carry out cool astronomical experiments at home.With easy-to-understand text written by science communicator and podcaster Izzie Clarke, and lots of colourful artworks, photos and diagrams, readers can best explore where we en

Brain Quest, America's #1 educational brand with more than 57 million copies in print, is now for babies! My First Brain Quest board books introduce essential early learning concepts and foundational vocabulary using engaging visuals and Brain Quest's signature question and answer format.From the rain in the sky to the grass at their feet, help your child understand the world around them with the guidance of this fun and exciting introduction to science!My First Brain Quest: First Words: Science Around Us introduces babies and toddlers to more than 100 STEM-related vocabulary words in their world—in the backyard, at the doctor's office, at the beach. Each scene features labeled illustrated objects as well as brief captions that help to introduce STEM concepts and help put into context, alongside questions that encourage conversation between reader and child. Children have fun naming, counting, and comparing.

During the early stages of its development, Taiwan’s New Literature was intimately connected with realism.The year 2022 is the one-hundredth anniversary of fiction writing in Taiwan, and also the one-hundredth anniversary of modernist literature in the English-speaking world. For the former, this is the one-hundredth anniversary of the publication of Chui Feng’s “Where Will She Go?” For the latter, it is the one-hundredth anniversary of the publication of James Joyce’s (1882–1941) novel Ulysses, and Anglo-American writer T. S. Eliot’s (1888–1965) poem The Waste Land. When the Alphabet Lab was first established, it also paid tribute to the contribution of modernism in the development of post-war Taiwan literature. In this special fiftieth issue on “Taiwan Fiction and ‘Realism,’” we once again identify and trace out the pathways and objectives of Taiwan’s writer apostles over the past one-hundred years.台灣新文學的發展，以追風的〈她要往何處去〉為濫觴，發表於1922年，至今剛好一百年。台灣新文學發軔時，歐美現代主義發展已達到高峰，台灣必然受到影響，可見現代主義與現實主義，

Take a large group of kids in puberty, send them to a new school, and add a generous dose of tests, homework, and hormones, not to mention diverse personalities, bland food, and unpleasant odors. That’s middle school, and it can be a little . . . weird.Yes, there are cool things about middle school, like more independence, new friends, and new activities. But there’s baffling stuff too, like harsh judgment, the whole “popularity” thing, and, of course, drama. With insights from hundreds of students, this guidebook explores the halls of middle school, especially the odd behaviors that lurk in the shadows. Slip-on your lab coats, because we’re going to dissect these behaviors one by one to understand what’s really going on. With fun illustrations and choose-your-own-adventure-style scenarios, Middle School: Safety Goggles Advised will help you deal with the drama and define who you are and how to navigate life when things get, well, weird.

Have fun and discover letter shapes in this moving-counter play book!Toddlers can start their writing journey without having to grasp a pen ­- just slide the counters around each track and have fun with the rhyming text!This book features curved tracks that mimic early handwriting patterns and with Waves and Wiggles little ones can become familiar with letter shapes: W, M, N, U and V. The five sliding counters in this book have fingerholes to help keep little hands steady and the rhyming narrative and bright illustrations from Ekaterina Trukhan will keep them entertained as they whizz around the tracks!This Learn&Play title:Boosts motor skillsIntroduces letter shapesRecommended for children 2+Look out for the other Ladybird Learn&Play title:Swirls and Squiggles

Have fun and discover letter shapes in this moving-counter play book!Toddlers can start their writing journey without having to grasp a pen ­- just slide the counters around each track and have fun with the rhyming text!This book features curved tracks that mimic early handwriting patterns and with Swirls and Squiggles little ones can become familiar with letter shapes: S, C, Z, E and O. The five sliding counters in this book have fingerholes to help keep little hands steady and the rhyming narrative and bright illustrations from Ekaterina Trukhan will keep them entertained as they whizz around the tracks!This Learn&Play title:Boosts motor skillsIntroduces letter shapesRecommended for children 2+Look out for the other Ladybird Learn&Play title:Waves and Wiggles

模糊統計遇上R語言，激盪出美麗的火花，成為您統計之路最好運用的工具！本書在模糊統計導論的基礎上，針對每種模糊統計分析方法提供R語言的撰寫語法，讓讀者更容易應用與計算。「當有人說他今天感到很快樂時，究竟他對於快樂的認知為何呢？什麼樣的測量標準可以稱得上快樂呢？或是這樣的感覺持續多久的時間以上才能算是快樂呢？」模糊理論是一種定量化處理人類語言、思維的新興學門。模糊邏輯並非如字面上意思那樣的馬虎、不精確，而是面對生活上各種的不確定性，以更合理的規則去分析及管理控制，以期得到更有效率、更合乎人性與智慧的結果。模糊統計並不模糊，它是處理不確定事件的新技術，帶領我們從古典的統計估計與檢定研究計算，進入一個需要軟計算、穩健性的高科技e世代。原本模糊統計導論就已經建構了相當完整的定義與計算公式，但苦於沒有容易操作使用的統計軟體平台，所幸R語言的成熟，提供了一個便於計算與理解模糊統計方法的平台，透過程式語言的撰寫，更能印證模糊統計方法的各種設想，而且也能由讀者自行撰寫更彈性與多元的語法，讓模糊統計的應用更為廣泛與深入。

'I want to be me! The glorious glittering me . . .People like me here Celestine! They adore me!'Victoria Stitch has escaped from the confines of Wiskling Wood and flown into the human world. Here, she breaks the most sacred of all wiskling laws and speaks to a human. Where she is feared and disgraced in Wiskling Wood, she is adored and revered in the human world.But the net is closing in. There are wisklings who would like to end Victoria Stitch's famous reign in the human world for good. Will her beloved twin, Celestine, be able to warn her in time? And even if she can, will Victoria Stitch listen?Review of Victoria Stitch: Bad and Glittering. This absorbing miniature melodrama is full of fraught sibling fondness between sweet, gentle Celestine and the marvellously ambitious and snooty Victoria, with Muncaster's own enticing illustrations. - The GuardianReview of Victoria Stitch: Bad and Glittering. Packed full of gothic glam and with a hefty dose of sparkles and glitter, Victoria Sti

資料分析聽起來很難，但只要你會用Excel，其實就不難上手了。透過這本實作指南，能夠幫助你更進一步地理解資料分析與處理，並瞭解如何藉助程式語言進行資料分析與假說檢定。 資料分析的重點是找出關聯性，本書可以引導你學到更進階的資料分析技術。本書運用試算表作為練習基礎統計學概念的範例，並告訴你如何運用Python與R進行更有效率的資料分析。 這本實用指南可以幫助你： ．了解如何利用Excel進行資料分析：透過Excel來測試變數之間的關係，並運用統計學製作令人信服的分析 ．從Excel到R：學會如何使用R進行原本利用Excel所進行的資料分析工作 ．從Excel到Python：學會如何應用Python進行原本利用Excel所進行的資料分析工作 ________________________________________ 專家推薦 「本書精確地說明如何運用Excel進行資料科學與分析的工作」--Jordan Goldmeier, 微軟Excel MVP 「這本書不僅可以作為商業和資料分析的參考資料，也可以作為入門教材」--Aiden Johnson, 資料科學家

The groundbreaking feminist and socialist writings of Puerto Rican author and activist Luisa Capetillo A Penguin Classic In 1915, Puerto Rican activist Luisa Capetillo was arrested and acquitted in 1915 for being the first woman to wear men's trousers publicly. While this act of gender-nonconforming rebellion elevated her to feminist icon status in modern pop culture, it also overshadowed the significant contributions she made to both the women's movement and anarchist labor movements of the early twentieth century--both in her native Puerto Rico and in the migrant labor belt in the eastern United States. With the volume A Nation of Women, Capetillo's socialist and feminist activism is given the spotlight it deserves with its inclusion of the first English translation of Capetillo's landmark Mi opini n sobre las libertades, derechos y deberes de la mujer. Originally published in Spanish in 1911, Mi opini n is considered by many to be the first feminist treatise in Puerto Rico and one o

With over 20 million copies sold in the US and Canada, and translated into more than 34 languages, Orson Scott Card's Ender series is one of Tor's all-time bestselling series, now repackaged for new r

It's gardening time! Can you rake the soil and plant the seeds?In this fun new series, little ones learn first words and experiences by using satisfying sliders and sturdy flaps. Each spread introduce

It's play time! Can you play on the swings and jump on the trampoline?In this fun new series, little ones learn first words and experiences by using satisfying sliders and sturdy flaps. Each spread in

◎詳細說明量化研究中資料處理。◎扎實的統計方法說明，提供不同情境的分析範例。◎以圖片詳實說明操作流程，同時輔助學習R語言。◎書中範例資料檔案請至五南網站https://www.wunan.com.tw，輸入書號1H0T下載。本書介紹R語言在量化資料分析上的應用，並從量化資料的各種分析方法中，以理論配合實例分析加以說明。內容共分為11章，分別是R語言簡介、量表題目分析、量表信度與效度分析、平均數差異

What secrets are hidden within the walls of a desolate farmhouse in a forgotten corner of Lapland?Early spring has its icy grip on Odesmark, a small village in northernmost Sweden, abandoned by many o

The second book in the delightfully sweet Heartstopper series, featuring beautiful two-color artwork! "Absolutely delightful. Sweet, romantic, kind. Beautifully paced. I loved this book." -- Rainbow R

From the author of the #1 New York Times bestseller On Tyranny comes an impassioned condemnation of America’s coronavirus response and an urgent call to rethink health and freedom.On December 29, 2019

Introduce your baby to first colours in this gorgeous pop-up book, illustrated by Nila Aye. Based on the popular tale of Little Red Riding Hood, a simplified story runs through the book for a shared r

Count to ten and race to launch your rocket first with this interactive learning game from Scholastic Early Learners! An innovative, math-focused learning game complete with QR-code guidance. Provides

Discover superhero Kung Pow Chicken, in this full-color early chapter book bind-up perfect for newly independent readers. Four books in one!Pick a book. Grow a Reader!This series is part of Scholastic

✎為實作派的你而寫――翻開本書，即刻上手！✔提供完整程式語言，對照參考不出錯✔多種程式碼撰寫範例，臨陣套用、現學現賣未來的國際通用語言只有一種――程式語言。FinTech強勢佔領金融市場，想在瞬息萬變的財金領域脫穎而出，就要具備程式語言邏輯的知能。●打造沉浸式R語言的學習環境本書用統計學觀點，檢視實際的財金時間序列資料，臨場感十足。讀取、計算、模擬、編表或繪圖，皆詳細收錄對應的R程式，不省略不馬虎

Oh no! It's raining. Can you help Bear put on his wellington boots and rain mac?In this fun new series, little ones learn first words and experiences by using satisfying sliders and sturdy flaps. Each

Who are you?What is your identity?What is racism?How do you choose your own path?How do you stand in solidarity?How can you hold yourself accountable?Learn about identities, true histories, and anti-r

序言《資料採礦寶典：使用R語言》是一本非常適合資料採礦(數據挖掘)初學者學習的一本教科書，不僅適合大學(本科)生上課使用，也適合研究生或老師進行研究時參考。作者潘文超教授是國際知名果蠅優化算法(Fruit Fly Optimization Algorithm)發明人，撰寫并发表了國際 SSCI,SCI 期刊論文40餘篇，曾經擔任國際知名SCI期刊編輯，對於眾多的資料採礦技術非常熟悉，深感目前市面上

從如何獲取、掌控、探索、預測與溝通資料認識現代資料科學應用您已經具備Python或R語言基礎程式設計能力，卻不曉得該如何應用所學來撰寫網頁爬蟲、連結資料庫、清理資料、資料視覺化或者機器學習嗎？這是為您量身打造的一本進階應用書，您將在本書找到用Python和R語言實踐前述這些迷人資料科學應用場景的實作範例！●用語平易近人、淺顯易讀●有效提升就學、研究與求職的即戰力●適合閱讀本書的讀者：已經能嫻熟使用

This draw-in activity book is packed with puzzles to solve, ideas to discover and objects to design. It explores some of the fundamental concepts that mathematicians use every day using just the conte

R. J. Palacio, #1 New York Times bestselling author of WONDER, hails this adventure series as "Mind-blowingly beautiful. . . . A must-read."Think Star Wars meets Avatar: The Last Airbender!In book 3,

Winner of the CWA Crime Awards Silver Dagger Two men lie in a welter of blood in the vestry of St Matthew's Church, Paddington, thier throats brutally slashed. One is Sir Paul Berowne, a baronet and r

This delightful interactive book is a charming introduction to the four seasons, changes in the weather, changes in the natural world and seasonal activities. A fun introduction to a key early learnin

The magic key takes Biff, Chip and Kipper to the bush in Grub Up. What will the children find for dinner in the bush? The non-fiction book that accompanies this title is Minibeasts Matter!. Oxford R

A charming, interactive introduction to space, exploring not just what's in space, but what it would be like to actually visit. Find out what you can hear, see and eat, and what living on Mars would r

Presents the letters of the alphabet with elements from the nineteen-fifties representing each letter, from A for atom and D for drive-in to H for hot rod and R for rock-n-roll.

Little ones will love using their fingers to follow the glittery, bumpy shiny trails in DK's Follow The Trail Trucks. This tactile board book is packed with colourful illustrations to help encourage e

The groundbreaking new colouring book that turns your pictures into animated films. Colour in the pictures, take photos using the free app and create your very own animated films based on your drawing