Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

A hilarious underground adventure starring the world's most adventurous family of pigs.When Mr. Mellops' golf ball rolls down a crevice, the family's natural response is to prepare a spelunking (cave

Jefferson Farjeon is quite unsurpassed for creepy skill in mysterious adventures.'Dorothy L. SayersRichard Temperley arrives at Euston station early on a fogbound London morning. He takes refuge in a

For a scream in the early hours of the morning in Soho, even from a female throat, to stop dead in his tracks a hard-boiled constable, it had to be something entirely out of the ordinary.' Soho during

HBO's hit series A GAME OF THRONES is based on George R R Martin's internationally bestselling series A SONG OF ICE AND FIRE, the greatest fantasy epic of the modern age. A DANCE WITH DRAGONS: DREAMS

On the eve of becoming a married man, the Counselor makes a risky entree into the drug trade—and gambles that the consequences won’t catch up to him.Along the gritty terrain of the Texas–Mexico border

It's report day in Classroom 5A located near the Mars Research Center. A new student, Cleopatra, shares her weekend adventure--she got to explore a dying planet! Using her holoband, Cleopatra shows th

In a land of perpetual night, your heart is your light.Reads R to L (Japanese Style), for audiences T. Amberground is locked in darkness. A man-made star casts only a dim light over the land. The pitc

Tashi lives in a tiny village below the tea plantations where her mother earns a living. One day her mother falls ill, and Tashi must pick tea to earn the money for a doctor. But she is too small to r

Reads R to L (Japanese Style), for audiences T The Lighthouse in the Wasteland? Lag finds his long-lost hero Gauche Suede! But Gauche’s heart is so depleted that he has no memory of his former self,

Reads R to L (Japanese Style) T audience.Asuka Masamune is a guy who loves girly things--sewing, knitting, making cute stuffed animals and reading shojo comics. But in a world where boys are expected

Reads R to L (Japanese Style) T audience. Amberground is locked in darkness. A man-made star casts only a dim light over the land. The pitch-black wilderness is infested with Gaichuu--colossal insect

Reads R to L (Japanese Style) T audience. Asuka Masamune is a guy who loves girly things--sewing, knitting, making cute stuffed animals and reading shojo comics. But in a world where boys are expecte

Reads R to L (Japanese Style). In a land of perpetual night, your heart is your light. Meeting Sylvette SuedeLag almost breaks the record time on his Letter Bee test, securing a job as a Letter Bee!

R to L (Japanese Style). Having Girly Hobbies Doesn't Make You Less Manly! Asuka's protégé Yamato has fallen in love with a girl and needs help winning her over. He pleads with Asuka to go

Dog loves books! Dog loves books about dinosaurs and Dog loves books about aliens: in fact Dog loves all books! Dog has his very own bookshop, although he doesn't have many customers. But that's all r

R to L (Japanese Style). In a land of perpetual night, your heart is your light. The Letter to Jiggy Pepper: Lag is close to becoming a Letter Bee! On the way to his final interview at the National P

R to L (Japanese Style)Asuka Masamune is a guy who loves girly things--sewing, knitting, making cute stuffed animals and reading shojo comics. But in a world where boys are expected to act manly, Asu

R to L (Japanese Style)The manga adapation of the legendary video game series, now available in English for the first time! Become part of the Legend – the Legend of Zelda!The Legend of Zelda i

R to L (Japanese Style)Asuka Masamune is a guy who loves girly things--sewing, knitting, making cute stuffed animals and reading shojo comics. But in a world where boys are expected to act manly, Asu

Exploring Traditional Chinese Festivals in China traces the history and development of various festivals celebrated in China. Many of these festivals have evolved into modern variations practiced in p

Delves into both the controversial sexual themes and neglected aspects of Schieles art, notably his formal experiments and his later expressionist portraits and allegorical paintings works that reveal

The real story of Little Red Riding Hood – told by the Wolf himself!Recounted in the confidential, conversational voice of a New York wheeler-dealer, this funny version of the Grimm Brothers' Little R

IT IS THE summer of 1938 when young Paul Moreaux discovers he can “fade.” First bewildered, then thrilled with the power of invisibility, Paul experiments. But his “gift” soon shows him shocking secre

Beep! Beep! Sheep in a jeep on a hill that’s steep. Sheep in a Jeep is well loved by the preschool and early-reader sets for its slapstick story of five sheep (in a jeep) and silly sound effects—espec

Play cubby with Bluey and Bingo in this board book with flaps.Bluey and Bingo are building a cubby for their toy, Kimjim. It includes an art room, a library and even an alpaca farm. Soon it’s so big, it’s easy to get lost in! What will Bluey and Bingo do when Kimjim goes missing? Lift the flaps in this board book to help find Kimjim!“It’s too many rooms!”Join Bluey and Bingo in this colourful board book with flaps and get lost in the cubby!Don’t miss these other awesome Bluey books:Bluey: GrandadBluey: Hide and SeekBluey: The WeekendBluey is an Emmy award-winning Australian children's television programme following the adventures of a loveable six-year-old Blue Heeler Puppy, Bluey and her family. It’s currently showing on Disney+, BBC iPlayer and CBeebies in the UK. Bluey enjoys exploring the world and using her imagination to turn everyday life into an amazing adventure. Join Bluey in this fun collection of story, activity and novelty books that celebrate play.

The second middle grade novel from number-one-bestselling author of The Appeal, Janice HallettThe second children’s murder mystery from number-one-bestselling author of The Appeal, Janice Hallett, perfect for fans of Robin Stevens and Rhian Tracey.Imagine an old museum with more secrets than anyone could ever guess. A school trip that ends in murder. A crime unsolved for decades. . . But who did it?Now, Ava and Luke are on the case, following the clues left in a new box of murders. Using School workbooks, museum records, secret recordings and letters the siblings start to unravel the mystery of a body in the basement. But can they discover what really happened . . . before the killer strikes again?YOU know the facts. YOU have all the clues. Can YOU solve the mystery before they do?Praise for A Box Full of Murders:'Pure catnip for budding young sleuths' The Telegraph

Move the slider mechanism to answer funny questions about baby farm animals and lift five flaps to find hidden creatures! Explore farm life in this interactive and playful board book, which places the child at the centre of the action. Each spread is packed with fun and includes an engaging question about the scene. Decide and slide to choose your answer! Inside you’ll discover: Six multiple choice questions explore different farm scenes.Vibrant, bold and funny illustrations from Susie Hammer will keep little ones entertained and engaged. A multi-sensory reading experience, with a slider and flaps to lift. Spot the Quizzy Bean characters on each spread and lift the flaps to find out who’s hiding. Encourages active engagement and interaction, and helps children to express their knowledge and preferences. Each title in the series explores key Early Years concepts across the questions, for example: shape, colour or size. From Rebecca Atkinson – best known for pre-school series Mixmups, wh

Move the slider mechanism to answer funny questions about the home and lift five flaps to find hidden creatures! It's bedtime in this interactive and playful board book, which places the child at the centre of the action. Each spread is packed with fun and includes an engaging question about the scene. Decide and slide to choose your answer! Inside you’ll discover: Six multiple choice questions explore different rooms in a house.Vibrant, bold and funny illustrations from Susie Hammer will keep little ones entertained and engaged. A multi-sensory reading experience, with a slider and flaps to lift. Spot the Quizzy Bean characters on each spread and lift the flaps to find out who’s hiding. Encourages active engagement and interaction, and helps children to express their knowledge and preferences. Each title in the series explores key Early Years concepts across the questions, for example: shape, colour or size. From Rebecca Atkinson – best known for pre-school series Mixmups, which airs

Join Bluey and Bingo for Daddy Drop Off!It’s Dad’s turn to get Bluey and Bingo ready for school and kindy, but the girls aren’t making things easy. Dad tries to keep the morning on track, but their games quickly derail the day. Join the fun in this Daddy Drop Off picture book!"Right, kids. Daddy Dropoff! We are NOT going to be late this time."Don’t miss these other awesome Bluey books:Bluey: The ShowBluey: Daddy RobotBluey: ZooBluey is an Emmy award-winning Australian children's television programme following the adventures of a loveable six-year-old Blue Heeler Puppy, Bluey and her family. It’s currently showing on Disney+, BBC iPlayer and CBeebies in the UK. Bluey enjoys exploring the world and using her imagination to turn everyday life into an amazing adventure. Join Bluey in this fun collection of story, activity and novelty books that celebrate play.

Mirabelle 和家人到海邊度假，但大家規定整個假期都不能使用魔法。對調皮的 Mirabelle 來說，這幾乎是不可能的事。她忍不住偷偷施了一點魔法，想創造一個神奇的小生物，卻意外變出一群可愛又麻煩的小龍寶寶。於是，一場充滿混亂與笑聲的魔法假期冒險就此展開。Mirabelle and her family are on holiday, staying in a lovely cottage by the sea. There's just one problem-they're not meant to be using magic.Can Mirabelle manage a whole week without any magical mischief? Of course not! But perhaps she can use a teeny bit of magic to create a magical creature? Just for one night . . .Half fairy, half witch, totally naughty!Mirabelle and her family are on holiday, staying in a lovely cottage by the sea. There's just one problem-they're not meant to be using magic.Can Mirabelle manage a whole week without any magical mischief? Of course not! But perhaps she can use a teeny bit of magic to create a magical creature? Just for one night . . .From the Mirabelle series:• Mirabelle Gets Up to Mischief (ISBN: 9780192776495)• Mirabelle Breaks the Rules (ISBN: 9780192777546)• Mirabelle Has a Bad Day (ISBN: 9780192777553)• Mirabelle I

Accelerate your toddler's education in first words and shapes using this engaging board book designed by a professional artist and licensed speech therapist Scribble Scrabble takes your young child on an adventure as they learn new words and shapes through life-like paintings, bright colors, and an animal friend who guides them along the way. Written by licensed speech therapist Tabitha Paige, Scribble Scrabble features strategically chosen first words that include a child's earliest developing sounds, such as m, b, p, t, etc. With beautiful hand-painted art from Tabitha, this is the perfect baby book for a baby shower gift! So join our little mouse friend on a creative adventure as he takes your child through this first words book in a fun and interactive way!

A quackingly new novelty book with lots of fun animals and sliders to push, pull and jiggle.With simple rhyming text, things to push pull and spin, and brilliant illustrations from Guilerhem Karsten, children will love to copy the movements of these animals and join in the jungle fun.A fun way to develop a child's physical development and encourage them to explore the way their bodies move as they trot like a horse, roll like a pig, peck like a hen and quack like a duck.Look out for Stomp Like an Elephant too!

A buzzing new novelty book with lots of fun animals and sliders to push, pull and jiggle.With simple rhyming text, things to push pull and spin, and brilliant illustrations from Guilerhem Karsten, children will love to copy the movements of these animals and join in the jungle fun.A fun way to develop a child's physical development and encourage them to explore the way their bodies move as they spin like a spider, hide like a snail, crawl like a caterpillar and buzz like a bee.Look out for Waddle Like a Duck too!

Hilarious chapter books about animals with jobs, clothes and superpowers! Highly illustrated in black and white and perfect for fans of the movies Sing and Zootropolis!Bob and Archie are two hapless but enthusiastic koalas who are just getting to grips with their new superpowers. Their archenemy is Dr Colossus, a giant ostrich with grand plans to destroy Pawtonia with the help of his Zombie Chickens!Can our furry heroes thwart the feathered supervillain? Definitely, maybe... This side-splitting, superhero series is the perfect early reader for young readers, where chapter books meet graphic novels!

Join Bluey and Bingo in this push-and-pull book and help them find all the critters! From witchetty grubs to butterflies, this interactive format is perfect for little Bluey fans. Slide the scroll bar, pull the tab and spin the wheel to discover what bugs are hiding in this book!“Hello, itchitty grubs!” Don’t miss these other awesome Bluey books:Bluey: A Big Pop-Up BookBluey: Outdoor Games: A Lift-the-Flap BookBluey: Toys: A Touch-and-Feel playbookBluey is an Emmy award-winning Australian children's television programme following the adventures of a loveable six-year-old Blue Heeler Puppy, Bluey and her family. It’s currently showing on Disney+, BBC iPlayer and CBeebies in the UK.Bluey enjoys exploring the world and using her imagination to turn everyday life into an amazing adventure. Join Bluey in this fun collection of story, activity and novelty books that celebrate play.

本書通過案例講述有關的概念和方法，不僅介紹了ARMA 模型、狀態空間模型、Kalman 濾波、單位根檢驗和GARCH 模型等一元時間序列方法，還介紹了很多多元時間序列方法，如線性協整、門限協整、VAR 模型、Granger 因果檢驗、神經網絡模型、可加AR 模型和譜估計等，並且增加了全新的一章講述如何用深度學習進行時間序列分析. 書中強調對真實的時間序列數據進行分析，全程使用R 和Python軟件分析了各個科學領域的實際數據，還分析了金融和經濟數據的例子.本書通俗易懂，理論與應用並重，可作為高等院校統計學和經濟管理等專業“時間序列分析”相關課程的教材，對金融和互聯網等領域的相關從業者也極具參考價值.

Happy Heelerween!Join Bluey and friends this Halloween in this mix-and-match book!Have fun mixing and matching as many as 50 different costumes with Bluey, Bingo, and all their friends. Turn a vampire into a ghost, a witch into a monster, and more! There’s lots of spooky fun to be had in this board play book. Don’t miss these other awesome Bluey books:Bluey: Let’s Get Spooky: A Magnet BookBluey: Hooray, it’s Halloween!Bluey: Goodnight Fruit BatBluey is an Emmy award-winning Australian children's television programme following the adventures of a loveable six-year-old Blue Heeler Puppy, Bluey and her family.It’s currently showing on Disney+, BBC iPlayer and CBeebies in the UK. Bluey enjoys exploring the world and using her imagination to turn everyday life into an amazing adventure. Join Bluey in this fun collection of story, activity and novelty books that celebrate play.

Learn all about love Bluey and Bingo style. Join the kiddos as they help prepare their parents for an evening of romance. What happens when they take a trip to the hairdressers? Can they make Bandit look even more handsome?Have fun with the Heeler family and learn all about the ways they show love in this romantic, lift-the-flap story.Don’t miss these other awesome Bluey books:Bluey: Love from BlueyBluey: I Love My FamilyBluey: Outdoor Games: A Lift-the-Flap BookBluey is an Emmy award-winning Australian children's television programme following the adventures of a loveable six-year-old Blue Heeler Puppy, Bluey and her family. It’s currently showing on Disney+, BBC iPlayer and CBeebies in the UK. Bluey enjoys exploring the world and using her imagination to turn everyday life into an amazing adventure.Join Bluey in this fun collection of story, activity and novelty books that celebrate play.

Learning how to read should be a walk in the dog park! Follow four curious canines on letter-replacement adventures in this phonics-based early reader series starter from Theodor Seuss Geisel Medalist Ethan Long.Meet the Letter Setters! When their BONE is GONE, these dynamic dogs—Patrick (an Irish Setter), R.W. (a Red and White Setter), Victoria (an English Setter), and Gordy (a Gordon Setter)—sound the GONG and spring into action to retrieve their tasty treat.In this engaging new early reader series from acclaimed author-illustrator Ethan Long, each story starts out with a four letter word. On the next page, one swapped letter makes a new word—and a new canine caper for little ones learning how to read! As this fresh and fun device propels the pups into silly, slapstick sequences, phonics help readers to discover new words, study how words relate to each other, and observe how text and pictures support one another.Geisel Medalist Ethan Long’s expressive artwork shines in these energet

★ 青蛙超級英雄登場！爆笑程度直逼《Dog Man》！★ 動作、笑點與環保主題完美結合，閱讀毫無負擔！★ 分段式冒險設計，培養孩子閱讀成就感！青蛙版超級英雄圖像小說，融合爆笑劇情與動作場面，講述兩位不太可靠的英雄對抗怪物與污染的故事。節奏快速、笑點密集，是喜歡《Dog Man》與輕鬆閱讀風格讀者的最佳選擇。The explosive first book in a new middle-grade graphic novel series featuring two heroic but dim-witted frog superheroes, for fans of InvestiGators and Dog Man!No one ever said it was easy being green! The contaminated swamp where Dr. Kim conducts experiments is overrun with mutants and evil machines like the Hater Gator and the Robot Trash Dolls. That's why she tinkered with amphibian genes to create superheroes Fantastic Frog and sidekick Tad Lad.In their first adventure, the frogs leap forth to battle the scaly swamp thing terrorizing Sector 1. Will the Hater Gator's tail flails flatten this duo before they discover the truth behind what's gone rotten in their swamp?And in their second adventure, the duo stumble upon a landfill of disgusting, off-brand toys in Sector 2 . . . which come alive! Outnumbered and totally grossed out, ca