Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

This book teaches children about the basic principles of science through 30 exciting experiments and crafts that can be done at home, using everyday objects and materials around you. Why do bubbles ho

繼電影《魔戒三部曲》之後，亞馬遜重啟開拍全新影集。透過《小人物大夢想》繪本認識這部奇幻史詩的作者J. R. R.托爾金。從南非搬到英國大城市，受困於水泥叢林進而使想像力的種子萌芽，成為當代奇幻文壇巨擘。In this book from the highly acclaimed Little People, BIG DREAMS series, discover the incredible life of J. R. R. Tolkien, author and forefather of the fantasy genre. Little John experienced lots of change in his life from a young age. Moving from South Africa to a big city in England, he longed for the nature he grew up around. After the death of both of his parents, John found comfort in telling stories and building imaginary worlds with his friends. And he continued to tell stories for the rest of his life, creating epic tales of hobbits, dwarves, elves, and wizards as J. R. R. Tolkien. This inspiring book features stylish and quirky illustrations and extra facts at the back, including a biographical timeline with historical photos and a detailed profile of the writer's life. Little People, BIG DREAMS is a bestselling series of books and educational games that explore the lives of ou

Big Data is made up of lots of little data: numbers entered into cell phones, addresses entered into GPS devices, visits to websites, online purchases, ATM transactions,

Using the same innovative format as his Caldecott Honor winner, Mel Fell, Corey R. Tabor reimagines Aesop’s “The Dog and His Reflection” in a clever, charming tale of empathy and generosity.One day, down by the pond, Simon meets another dog just like him.And that dog has a bone just like his, only better!How will Simon ever get him to trade, when the other pup knows all the same tricks...?This is another delightfully surprising tale from the award-winning creator of Mel Fell.

Filled with practical, everyday activities that build language development and early literacy into your daily schedule. Use circle time, snack time, dramatic play or any other time throughout the day

An interdisciplinary, cross-cultural collection that decenters familiar narratives to provide a fresh perspective on what artificial intelligence is today, and what it might become.Historians, media theorists, science-fiction writers, philosophers, and artists from China and elsewhere reexamine the nation’s intense engagement with AI, moving beyond the clichés that still dominate contemporary debate.Today, visions of the contested future of AI veer between common planetary goals and a new Cold War, as culturally-specific models of intelligence, speculative traditions, and thought experiments come up against the emergence of novel forms of cognition that cannot be reduced to any historical cultural tradition.This uniquely positioned volume provides expert insight into this tension, using China as a touchstone for rethinking "artificiality" and "intelligence" as sites of difference in a way that is already present in the difficulty of precisely translating the Chinese term 人工智能. Tracking

Caldecott Medal-winner and #1 New York Times-bestselling author Kevin Henkes explores what it means to be at home in this stunning picture book. Brimming with interactive call-and-response questions,

Soccer is the most mathematical of sports--riddled with numbers, patterns, and shapes. How to make sense of them? The answer lies in mathematical modeling, a science with applications in a host of bio

A NEW ORIGINAL SERIES, NOW ON HBO.Here is the first volume in George R. R. Martin’s magnificent cycle of novels that includes A Clash of Kings and A Storm of Swords. As a whole, this series comprises

GAME OF THRONES: A NEW ORIGINAL SERIES, NOW ON HBO.Here is the third volume in George R. R. Martin’s magnificent cycle of novels that includes A Game of Thrones and A Clash of Kings. As a whole, this

Created by a teacher, Bob Books have been helping children learn to read for more than forty years! This set gives children who are just beginning to read practice with their early phonics skills, setting them up for success on their reading journeys!With playful stories, silly illustrations, and a phonics approach based on Science of Reading research, Bob Books keep young readers'' confidence high, leading to continued success and a love of reading. Your child will soon join the millions of happy kids who say, "I read the whole book!"®Science of Reading research proves that mastering phonics is key to a child''s success in learning to read. Like all Stage 1 Bob Books, these 12 storybooks feature simple words with consistent short vowel sounds. Early readers get lots of practice with foundational phonics skills while giggling at the playful stories and pictures!This set is perfect for children who have never read Bob Books, or for children who have read Bob Books Beginning Readers or B

三位創作者 Ben Clanton、Corey R. Tabor 與 Andy Chou Musser 攜手打造的創意繪本，以幽默與想像力描繪毛毛蟲 Papilio Polyxenes 的成長之旅。她滿懷期待想成為蝴蝶，卻在學飛、覓食、躲避天敵的過程中跌跌撞撞。故事分為三個篇章，語氣俏皮又富節奏感，畫風多變而充滿生命力，讓孩子隨著 Papilio 一同體驗「長大的不容易」與「相信自己的勇氣」。A tale told in three parts by three friends! Powerhouse creators, Ben Clanton, Corey R. Tabor, and Andy Chou Musser, have come together to create a wholly inventive picture book that is perfect for fans of The Very Hungry Caterpillar. Introducing Papilio Polyxenes, the Black Swallowtail Butterfly! She's an adorable and hilarious caterpillar who is ready to join the world and become a butterfly! But growing up is a complicated work in progress, and Papilio encounters some hiccups as she learns to fly, fall, and feed. While avoiding foes and making friends, she transforms from caterpillar, to chrysalis, to butterfly...and most importantly, learns to believe in herself along the way. Told in three parts, mega-bestselling author-illustrator Ben Clanton, Caldecott Honoree Corey R. Tabor, and risi

Matt Tavares’s sequel to the New York Times best-selling Dasher is a joyful ode to helping others—and another holiday classic in the making.“If you ever get lost, just look for the North Star.”With only one sleep left before Christmas Eve, Dasher can’t contain her excitement for her favorite holiday. With the sound of Christmas carols on the breeze and twinkling lights radiating from a nearby city, she sneaks off to visit the festivities. But as night deepens and snow starts to fall, Dasher realizes she can no longer spot the North Star in the sky to lead her home. Will the kindness of a child, an unexpected gift, and a dose of Christmas spirit get her back in time to help guide Santa’s sleigh? The New York Times best-selling creator of Dasher has crafted another delightful journey featuring everyone’s favorite reindeer doe, in a story full of giving, joy, and holiday magic.

Lively illustrations by well-known artist and illustrator Kaley McKeanSupports science teaching in schoolsFirst in an exciting, bright new series of lift-the-flap books - 'How It Works'An ILLUMINATING introduction to the science of lightLift the flaps to discover what light is, where it comes from and how it works, from rainbows and reflections to lightyears and lasers. Then see light in action for yourself by trying out some simple home experiments.

Even if trapped in darkness, one will always search for the light.This is a story of a young police officer searching for the answer to "Who am I?"In the past, Xie Lanshan was an undercover drug enforcement officer who infiltrated the Golden Triangle's most feared armed organization as drug lord Mu Kun's right-hand man. After successfully returning to his post from the operation, an accidental case of police misconduct triggers a series of unexplainable headaches and hidden memories that begin to haunt him.While investigating the truth behind his father's death of many years ago, Xie Lanshan utilizes his unique and sharp thinking from the perspective of a psychotic murderer to solve difficult cases around him. Plagued by this growing change and instability of both his mental health and personality, he meets a mysterious forensic sketch artist named Shen Liufei. Together, the two men will maintain a strange relationship; as friends and enemies, they solve mysterious cases one by one.But

Aspiring astronauts will be ready for liftoff with this thrilling guide to preparing for and doing a real spacewalk with the first American woman to walk in space as their partner.What is it like to walk in space—to use cutting-edge equipment and conduct experiments in a 280-pound space suit? How do you get there in the first place? Would-be spacewalkers will find enthusiasm, vibrant encouragement, and a host of amazing facts, photos, drawings, and descriptions in this engaging guide cowritten by three-time shuttle astronaut Kathryn D. Sullivan and children’s book author Michael J. Rosen (who also provides illustrations). From detailed info about how to train (sometimes underwater!) to descriptions of the emotions spurred by seeing Earth from above, this guide will leave readers inspired and excited to start their own journeys into space.

Hello, USA! This delightful board book from Hello, World creator Ashley Evanson pairs early learning concepts with colorful, stylish illustrations of the iconic art, architecture, food, and culture from all 50 US states.In Hello, USA! A Book of Beginner Concepts, readers learn all about the 50 states through five sections of early reading concepts (numbers, months, colors, shapes, and opposites): from the eight iconic stripes on Maine's Acadia Lighthouse to four purple wildflowers in Montana's Glacier National Park to the colorful rectangle houses in South Carolina's Charleston, and more -- all in Ashley Evanson's dynamic Hello, World style.

From the multi-award winning author of The Bridge (BBC) and Marcella (Netflix, ITV) comes a blockbuster new thriller… A DEAD WOLFA DRUG DEAL GONE WRONGA LETHAL FEMALE ASSASSINHannah Wester, a detective in the remote northern Swedish town of Haparanda, finds herself on the precipice of chaos.When human remains are found in the stomach of a dead wolf, Hannah knows that this summer won’t be like any other. The remains are soon linked to a bloody drug deal that went down just across the border in Finland. But how did the victim end up in the woods outside Haparanda? And where have the drugs and money gone?Hannah and her colleagues are soon caught up in an increasingly complex investigation. But time is scarce and they aren’t the only ones looking.When the secretive and deadly Katja shows up, unexpected and brutal events start to pile up. In just a few days, life in the border town is turned upside down. Not least for Hannah, who is finally forced to confront her own past.

A beautifully illustrated and insightful anthology to return to time and again. We all have days when we find ourselves in need of some positivity. In difficult times, the words of others can lift us up. Bright, joyful art to inspire hopefulness is combined with carefully curated poems, chosen to lift the spirits through the healing power of words. The book is divided into eight sections on the themes of Joy, Hope, Resilience, Nature, Tranquillity, Gratitude, Escape and Love. Featuring a diverse range of writers from Maya Angelou to Oscar Wilde, Pablo Neruda to Rupi Kaur, the selections are accompanied by explanations and illuminating context that reinforces the positive mental health message. Combining uplifting lines of verse and joyful illustrations, this unique book provides a much-needed dose of hopefulness and happiness in turbulent times, whether as a thoughtful gift for someone in need of solace or a resource that can be turned to whenever we need to.

It's a dark and stormy night and Toby cannot sleep. The whole house seems to be tossing and turning like a ship in the middle of the ocean...and soon Toby enters a fantasy world where he is indeed at sea, caught up in a strange and wild adventure. Luckily, Toby's cat makes up the crew of his ship, and together they chart a course through the storm and fend off a giant sea monster - with the last minute help of a mystery submarine which comes to their aid.But hang on, the submarine is manned by his Grandma and Grandpa! Soon they are back in the safety of the harbour, ready for breakfast - but lift the flap for one last surprise! Dramatic and surreal, there is danger and bravery with a large dose of the surreal, and lots more to notice on every re-read.

It's not always easy being a LEGO (R) minifigure. Welcome to the wacky LEGO world, where minifigures of all sorts navigate life, love, and leisure in miniature. Whether they are out at poker night,

When Appleton Elementary''''s new school board president starts using her position to line her own pockets, it''''s up to student sleuths, supported by a passionate librarian, to uncover the truth in

Access in easy steps has an easy-to-follow style that will appeal to anyone who wants to get more from the Microsoft Access app. Whether you’re using Access in the Office 365 suite or standalone Offic

Unforgettable Ancient Sites includes mysterious megalithic sites that appear to have been built using geometric principles far in advance of their time, pyramids that once ran with sacrificial blood,

Sherlock Holmes is back on the case in this collection of sparkling short stories, in which we learn about Holmes' early days as a sleuth, encounter a seemingly murderous widow, and meet the great det

Working in partnership with the RSC, this brand new series is ideal for introducing students to Shakespeare's plays. Using trusted and established RSC approaches, Shakespeare's plays come to life in t

Do you know that water covers nearly 70 percent of the earth and that nearly 70 percent of the human body is made up of H2O? That more than half of the earth's species live in water? Or that the sea r

A little witch named Delia has been looking forward all year to flying in the annual Witch Parade. When the rumors of rain come true and the other witches start complaining, Delia takes action. Using

This nontechnical guide provides helpful advice and insight for those who are in an intimate relationship with someone diagnosed with Asperger syndrome. Although the American Psychiatric Association r

Brilliantly evoking the long-vanished world of masters and servants portrayed in Downton Abbey and Upstairs, Downstairs, Margaret Powell’s classic memoir of her time in service, Below Stairs, is the r

BESTSELLING AUTHORS GO HOLMES—IN AN IRRESISTIBLE NEW COLLECTION edited by award-winning Sherlockians Laurie R. King and Leslie S. Klinger?Neil Gaiman. Laura Lippman. Lee Child. These are just three of

The year is 2054, and life has been reduced to a data feed. The fusing of virtual reality and cybernetics has ushered in the era of the surrogate, a new technology that lets users interact with the wo

The Lottery, one of the most terrifying stories written in this century, created a sensation when it was first published in The New Yorker. "Power and haunting," and "nights of unrest" were typical r

This magnificent novel—which secured for its author the 1955 Nobel Prize in Literature—is at least available to contemporary American readers. Although it is set in the early twentieth century, it rec

2025’s INSTANT No.1 SUNDAY TIMES best-seller from the author of YELLOWFACEPrepare for one hell of a journey…'A big, bold fantasy romp' GUARDIAN'R.F. Kuang is making magic' ELLE'[A] truly original and spellbinding hero's-journey story' VOGUE'I devoured it' REDOne of the BBC's 25 best books of 2025Katabasis, noun, Ancient Greek. The story of a hero's descent to the underworld.Grad student Alice Law has only ever had one goal: to become the brightest mind in the field of analytic magick.But the only person who can make her dream come true is dead and – inconveniently – in Hell. And Alice, along with her biggest rival Peter Murdoch, is going after him.But Hell is not as the philosophers claim, its rules are upside-down, and if she’s going to get out of there alive, she and Peter will have to work together.That’s if they can agree on anything.Will they triumph, or kill each other trying?2025’s most unexpected love story is going to be hell in the new No.1 Sunday Times bestselling novel by R

如果有一天變成熊，你會做什麼？在本書中，「我」一早醒來，吃早餐、騎摩托車，還順手拯救被熱氣球帶走的好朋友——這些都是再正常不過的「熊日常」。當然，不可能站在全班面前做一份無聊又詳盡的熊類報告吧？Corey R. Tabor 以第一人稱視角巧妙鋪陳，讓讀者彷彿成了那隻熊，畫面邊緣還能看見熊的手腳晃動，幽默感十足。故事在出其不意的轉折中揭露真正的說話者，也溫柔回應孩子對上台報告的緊張。曾獲 Caldecott Honor 與三座 Geisel Award 的作者，再次帶來兼具創意與笑點的圖畫書。Assignment: Imagine yourself as a bear for the day. What would you do? Caldecott Honor and three-time Geisel Award–winning author and illustrator Corey R. Tabor offers an inspiring—and surprising—answer in this funny picture book for fans of Mo Willems, David Shannon, and Peter Brown.If you were a bear for a day, what would you do? Probably wake up, eat breakfast, go for a motorcycle ride, and rescue your best friend from a rogue hot air balloon. . . . You know, normal bear stuff!You certainly wouldn’t stand in front of the whole class and give a boring, detailed, and informational report about bears.Dynamically illustrated from the bear’s perspective, the Caldecott Honor and three-time Geisel Award–winning Corey R. Tabor delivers an innovati

Doctor Strange, one of Marvel’s most fascinating early characters, began at the hands of co-creators Stan Lee and Steve Ditko, and his ethereal voyages through other dimensions made him an important figure in 1960s culture.From his first appearance in 1963, Strange captivated a wide range of readers. Over his first ten years, a succession of writers and artists—including Roy Thomas, Gene Colan, Gardner F. Fox, P. Craig Russell, Marie Severin, and notably Steve Englehart and Frank Brunner—expanded on Ditko’s original mind-bending concepts.This entry in the MARVEL AGE OF COMICS explores Strange’s changing roles as a mystic, super hero, and leader of a chaotic team called the Defenders, and the rise of his popularity, in parallel with the counterculture of the 1960s.

DISCOVER THE CULT HIT THAT BECAME A WORLDWIDE PHENOMENON The Dregs Edition of the #1 New York Times bestseller Crooked Kingdom, sequel to Six of Crows, features new cover art, black stained edges, and updated maps. When you can't beat the odds, change the game. Kaz Brekker and his crew have just pulled off a heist so daring even they didn't think they'd survive. But instead of divvying up a fat reward, they're right back to fighting for their lives. Double-crossed and badly weakened, the crew is low on resources, allies, and hope. As powerful forces from around the world descend on Ketterdam to root out the secrets of the dangerous drug known as jurda parem, old rivals and new enemies emerge to challenge Kaz's cunning and test the team's fragile loyalties. A war will be waged on the city's dark and twisting streets--a battle for revenge and redemption that will decide the fate of the world as they know it. "Dark, larcenous fun." --NPR "Bardugo outdoes herself in this exhilarating follo

Dante’sInfernomeetsSusanna Clarke’sPiranesiin this all-new dark academia fantasyfrom R. F. Kuang, the #1New York Timesbestselling author ofBabel and Yellowface,in which two graduate students must put aside their rivalry and journey to Hell to save their professor’s soul—perhaps at the cost of their own.Katabasis, noun, Ancient Greek:The story of a hero’s descent to the underworldAlice Law has only ever had one goal: to become one of the brightest minds in the field of Magick. She has sacrificed everything to make that a reality: her pride, her health, her love life, and most definitely her sanity. All to work with Professor Jacob Grimes at Cambridge, the greatest magician in the world.That is, until he dies in a magical accident that could possibly be her fault.Grimes is now in Hell, and she’s going in after him. Because his recommendation could hold her very future in his now incorporeal hands and even death is not going to stop the pursuit of her dreams….Nor will the fact that her ri

★ 爆笑科學任務登場！用物理實驗拯救奶奶、破解超荒謬危機★ 圖像漫畫風＋實驗活動，一邊大笑一邊動手做科學★ 英國暢銷童書作家 Swapna Haddow × 科學漫畫家 Jess Bradley★ 15種超好玩的 STEM 實驗，從「蛋殼橋」到「電磁鐵」都能自己試一本把科學變成爆笑冒險任務的圖像科普書。孩子將在「拯救奶奶」、「阻止火車」、「騙過鯊魚」等瘋狂情境中，透過簡單有趣的實驗理解物理原理。結合漫畫式插圖與動手做活動，讓 STEM 不再枯燥，而是一場充滿驚喜與笑聲的科學冒險。A funny children’s illustrated science book with experiments for ages 8+ that is new for 2025Bonkers dilemmas that can be solved with science and a bunch of brilliant physics experiments.Book of the Week: The Week Junior***No grannies were harmed in the making of this book!**Trick a shark! Lift a jumbo jet! Escape a deserted island! Stop a runaway train!Explore a bunch of ridiculous (and not-so-ridiculous) dilemmas – with solutions from the astonishing world of physics.Sounds unbelievable? Test the science for yourself, with easy-to-follow experiments throughout!What are you waiting for? Let’s save Granny!Written by bestselling and award-winning author Swapna Haddow, with brilliantly funny colour illustrations from award-winning illustrator Jess Br