Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

This jam-packed collection of fun and simple science experiments for kids is perfect for the classroom or home. Stir up some sticky slime, build a solar system with rubber bands, power a speed boat using soap, and construct an erupting volcano, all with Home Activity Lab, which offers exciting experiments for budding scientists. Including a foreword by Professor Robert Winston, this stunning book includes 28 brilliant science projects using simple step-by-step instructions, everyday ingredients that can be found around the house, and amazing photography to guide you from start to finish. Each experiment describes the science behind the project, highlighting STEM facts with STEM icons pointing out the key science, technology, engineering, and math learning involved in each project. "Take it further" panels encourage young readers to experiment and take their projects to the next level, developing their independence, initiative, and creative thinking skills. Perfect for budding scientist

This book teaches children about the basic principles of science through 30 exciting experiments and crafts that can be done at home, using everyday objects and materials around you. Why do bubbles ho

繼電影《魔戒三部曲》之後，亞馬遜重啟開拍全新影集。透過《小人物大夢想》繪本認識這部奇幻史詩的作者J. R. R.托爾金。從南非搬到英國大城市，受困於水泥叢林進而使想像力的種子萌芽，成為當代奇幻文壇巨擘。In this book from the highly acclaimed Little People, BIG DREAMS series, discover the incredible life of J. R. R. Tolkien, author and forefather of the fantasy genre. Little John experienced lots of change in his life from a young age. Moving from South Africa to a big city in England, he longed for the nature he grew up around. After the death of both of his parents, John found comfort in telling stories and building imaginary worlds with his friends. And he continued to tell stories for the rest of his life, creating epic tales of hobbits, dwarves, elves, and wizards as J. R. R. Tolkien. This inspiring book features stylish and quirky illustrations and extra facts at the back, including a biographical timeline with historical photos and a detailed profile of the writer's life. Little People, BIG DREAMS is a bestselling series of books and educational games that explore the lives of ou

Big Data is made up of lots of little data: numbers entered into cell phones, addresses entered into GPS devices, visits to websites, online purchases, ATM transactions,

Using the same innovative format as his Caldecott Honor winner, Mel Fell, Corey R. Tabor reimagines Aesop’s “The Dog and His Reflection” in a clever, charming tale of empathy and generosity.One day, down by the pond, Simon meets another dog just like him.And that dog has a bone just like his, only better!How will Simon ever get him to trade, when the other pup knows all the same tricks...?This is another delightfully surprising tale from the award-winning creator of Mel Fell.

Loved by millions of children, these classic peekaboo books are now gathered together in a boxed set that's ideal for gift giving—and for giving story time an extra dose of fun! Showcasing animals, ve

Caldecott Medal-winner and #1 New York Times-bestselling author Kevin Henkes explores what it means to be at home in this stunning picture book. Brimming with interactive call-and-response questions,

Soccer is the most mathematical of sports--riddled with numbers, patterns, and shapes. How to make sense of them? The answer lies in mathematical modeling, a science with applications in a host of bio

A NEW ORIGINAL SERIES, NOW ON HBO.Here is the first volume in George R. R. Martin’s magnificent cycle of novels that includes A Clash of Kings and A Storm of Swords. As a whole, this series comprises

GAME OF THRONES: A NEW ORIGINAL SERIES, NOW ON HBO.Here is the third volume in George R. R. Martin’s magnificent cycle of novels that includes A Game of Thrones and A Clash of Kings. As a whole, this

Filled with practical, everyday activities that build language development and early literacy into your daily schedule. Use circle time, snack time, dramatic play or any other time throughout the day

Created by a teacher, Bob Books have been helping children learn to read for more than forty years! This set gives children who are just beginning to read practice with their early phonics skills, setting them up for success on their reading journeys!With playful stories, silly illustrations, and a phonics approach based on Science of Reading research, Bob Books keep young readers'' confidence high, leading to continued success and a love of reading. Your child will soon join the millions of happy kids who say, "I read the whole book!"®Science of Reading research proves that mastering phonics is key to a child''s success in learning to read. Like all Stage 1 Bob Books, these 12 storybooks feature simple words with consistent short vowel sounds. Early readers get lots of practice with foundational phonics skills while giggling at the playful stories and pictures!This set is perfect for children who have never read Bob Books, or for children who have read Bob Books Beginning Readers or B

三位創作者 Ben Clanton、Corey R. Tabor 與 Andy Chou Musser 攜手打造的創意繪本，以幽默與想像力描繪毛毛蟲 Papilio Polyxenes 的成長之旅。她滿懷期待想成為蝴蝶，卻在學飛、覓食、躲避天敵的過程中跌跌撞撞。故事分為三個篇章，語氣俏皮又富節奏感，畫風多變而充滿生命力，讓孩子隨著 Papilio 一同體驗「長大的不容易」與「相信自己的勇氣」。A tale told in three parts by three friends! Powerhouse creators, Ben Clanton, Corey R. Tabor, and Andy Chou Musser, have come together to create a wholly inventive picture book that is perfect for fans of The Very Hungry Caterpillar. Introducing Papilio Polyxenes, the Black Swallowtail Butterfly! She's an adorable and hilarious caterpillar who is ready to join the world and become a butterfly! But growing up is a complicated work in progress, and Papilio encounters some hiccups as she learns to fly, fall, and feed. While avoiding foes and making friends, she transforms from caterpillar, to chrysalis, to butterfly...and most importantly, learns to believe in herself along the way. Told in three parts, mega-bestselling author-illustrator Ben Clanton, Caldecott Honoree Corey R. Tabor, and risi

Matt Tavares’s sequel to the New York Times best-selling Dasher is a joyful ode to helping others—and another holiday classic in the making.“If you ever get lost, just look for the North Star.”With only one sleep left before Christmas Eve, Dasher can’t contain her excitement for her favorite holiday. With the sound of Christmas carols on the breeze and twinkling lights radiating from a nearby city, she sneaks off to visit the festivities. But as night deepens and snow starts to fall, Dasher realizes she can no longer spot the North Star in the sky to lead her home. Will the kindness of a child, an unexpected gift, and a dose of Christmas spirit get her back in time to help guide Santa’s sleigh? The New York Times best-selling creator of Dasher has crafted another delightful journey featuring everyone’s favorite reindeer doe, in a story full of giving, joy, and holiday magic.

Lively illustrations by well-known artist and illustrator Kaley McKeanSupports science teaching in schoolsFirst in an exciting, bright new series of lift-the-flap books - 'How It Works'An ILLUMINATING introduction to the science of lightLift the flaps to discover what light is, where it comes from and how it works, from rainbows and reflections to lightyears and lasers. Then see light in action for yourself by trying out some simple home experiments.

Even if trapped in darkness, one will always search for the light.This is a story of a young police officer searching for the answer to "Who am I?"In the past, Xie Lanshan was an undercover drug enforcement officer who infiltrated the Golden Triangle's most feared armed organization as drug lord Mu Kun's right-hand man. After successfully returning to his post from the operation, an accidental case of police misconduct triggers a series of unexplainable headaches and hidden memories that begin to haunt him.While investigating the truth behind his father's death of many years ago, Xie Lanshan utilizes his unique and sharp thinking from the perspective of a psychotic murderer to solve difficult cases around him. Plagued by this growing change and instability of both his mental health and personality, he meets a mysterious forensic sketch artist named Shen Liufei. Together, the two men will maintain a strange relationship; as friends and enemies, they solve mysterious cases one by one.But

Aspiring astronauts will be ready for liftoff with this thrilling guide to preparing for and doing a real spacewalk with the first American woman to walk in space as their partner.What is it like to walk in space—to use cutting-edge equipment and conduct experiments in a 280-pound space suit? How do you get there in the first place? Would-be spacewalkers will find enthusiasm, vibrant encouragement, and a host of amazing facts, photos, drawings, and descriptions in this engaging guide cowritten by three-time shuttle astronaut Kathryn D. Sullivan and children’s book author Michael J. Rosen (who also provides illustrations). From detailed info about how to train (sometimes underwater!) to descriptions of the emotions spurred by seeing Earth from above, this guide will leave readers inspired and excited to start their own journeys into space.

Hello, USA! This delightful board book from Hello, World creator Ashley Evanson pairs early learning concepts with colorful, stylish illustrations of the iconic art, architecture, food, and culture from all 50 US states.In Hello, USA! A Book of Beginner Concepts, readers learn all about the 50 states through five sections of early reading concepts (numbers, months, colors, shapes, and opposites): from the eight iconic stripes on Maine's Acadia Lighthouse to four purple wildflowers in Montana's Glacier National Park to the colorful rectangle houses in South Carolina's Charleston, and more -- all in Ashley Evanson's dynamic Hello, World style.

From the multi-award winning author of The Bridge (BBC) and Marcella (Netflix, ITV) comes a blockbuster new thriller… A DEAD WOLFA DRUG DEAL GONE WRONGA LETHAL FEMALE ASSASSINHannah Wester, a detective in the remote northern Swedish town of Haparanda, finds herself on the precipice of chaos.When human remains are found in the stomach of a dead wolf, Hannah knows that this summer won’t be like any other. The remains are soon linked to a bloody drug deal that went down just across the border in Finland. But how did the victim end up in the woods outside Haparanda? And where have the drugs and money gone?Hannah and her colleagues are soon caught up in an increasingly complex investigation. But time is scarce and they aren’t the only ones looking.When the secretive and deadly Katja shows up, unexpected and brutal events start to pile up. In just a few days, life in the border town is turned upside down. Not least for Hannah, who is finally forced to confront her own past.

A beautifully illustrated and insightful anthology to return to time and again. We all have days when we find ourselves in need of some positivity. In difficult times, the words of others can lift us up. Bright, joyful art to inspire hopefulness is combined with carefully curated poems, chosen to lift the spirits through the healing power of words. The book is divided into eight sections on the themes of Joy, Hope, Resilience, Nature, Tranquillity, Gratitude, Escape and Love. Featuring a diverse range of writers from Maya Angelou to Oscar Wilde, Pablo Neruda to Rupi Kaur, the selections are accompanied by explanations and illuminating context that reinforces the positive mental health message. Combining uplifting lines of verse and joyful illustrations, this unique book provides a much-needed dose of hopefulness and happiness in turbulent times, whether as a thoughtful gift for someone in need of solace or a resource that can be turned to whenever we need to.

It's a dark and stormy night and Toby cannot sleep. The whole house seems to be tossing and turning like a ship in the middle of the ocean...and soon Toby enters a fantasy world where he is indeed at sea, caught up in a strange and wild adventure. Luckily, Toby's cat makes up the crew of his ship, and together they chart a course through the storm and fend off a giant sea monster - with the last minute help of a mystery submarine which comes to their aid.But hang on, the submarine is manned by his Grandma and Grandpa! Soon they are back in the safety of the harbour, ready for breakfast - but lift the flap for one last surprise! Dramatic and surreal, there is danger and bravery with a large dose of the surreal, and lots more to notice on every re-read.

It's not always easy being a LEGO (R) minifigure. Welcome to the wacky LEGO world, where minifigures of all sorts navigate life, love, and leisure in miniature. Whether they are out at poker night,

When Appleton Elementary''''s new school board president starts using her position to line her own pockets, it''''s up to student sleuths, supported by a passionate librarian, to uncover the truth in

Access in easy steps has an easy-to-follow style that will appeal to anyone who wants to get more from the Microsoft Access app. Whether you’re using Access in the Office 365 suite or standalone Offic

Unforgettable Ancient Sites includes mysterious megalithic sites that appear to have been built using geometric principles far in advance of their time, pyramids that once ran with sacrificial blood,

Sherlock Holmes is back on the case in this collection of sparkling short stories, in which we learn about Holmes' early days as a sleuth, encounter a seemingly murderous widow, and meet the great det

Working in partnership with the RSC, this brand new series is ideal for introducing students to Shakespeare's plays. Using trusted and established RSC approaches, Shakespeare's plays come to life in t

Do you know that water covers nearly 70 percent of the earth and that nearly 70 percent of the human body is made up of H2O? That more than half of the earth's species live in water? Or that the sea r

A little witch named Delia has been looking forward all year to flying in the annual Witch Parade. When the rumors of rain come true and the other witches start complaining, Delia takes action. Using

This nontechnical guide provides helpful advice and insight for those who are in an intimate relationship with someone diagnosed with Asperger syndrome. Although the American Psychiatric Association r

Brilliantly evoking the long-vanished world of masters and servants portrayed in Downton Abbey and Upstairs, Downstairs, Margaret Powell’s classic memoir of her time in service, Below Stairs, is the r

BESTSELLING AUTHORS GO HOLMES—IN AN IRRESISTIBLE NEW COLLECTION edited by award-winning Sherlockians Laurie R. King and Leslie S. Klinger?Neil Gaiman. Laura Lippman. Lee Child. These are just three of

The year is 2054, and life has been reduced to a data feed. The fusing of virtual reality and cybernetics has ushered in the era of the surrogate, a new technology that lets users interact with the wo

Dante’sInfernomeetsSusanna Clarke’sPiranesiin this all-new dark academia fantasyfrom R. F. Kuang, the #1New York Timesbestselling author ofBabel and Yellowface,in which two graduate students must put aside their rivalry and journey to Hell to save their professor’s soul—perhaps at the cost of their own.Katabasis, noun, Ancient Greek:The story of a hero’s descent to the underworldAlice Law has only ever had one goal: to become one of the brightest minds in the field of Magick. She has sacrificed everything to make that a reality: her pride, her health, her love life, and most definitely her sanity. All to work with Professor Jacob Grimes at Cambridge, the greatest magician in the world.That is, until he dies in a magical accident that could possibly be her fault.Grimes is now in Hell, and she’s going in after him. Because his recommendation could hold her very future in his now incorporeal hands and even death is not going to stop the pursuit of her dreams….Nor will the fact that her ri

A love letter to books, showing how many elements and people contribute to making something beautiful, from Caldecott honoree Elisha Cooper In this poetic and beautifully illustrated ode to creativity and the process of making books, Caldecott honoree Elisha Cooper takes readers on a journey showing how words and art move from one person to another. From writer to reader, and everyone who contributes in between: Here is a book, made with love. An artist's studio overflows with sketches, drafts, a wastebasket, and wonder. A publisher's office hums with computers, layouts, coffee, and teamwork. A printer makes a layout into a book using presses, ink, paper, and time. And that book travels to a school, to a library, to a student, to a home.

《Troubled》是一本動人且引人深思的回憶錄，講述Rob Henderson從破碎家庭、寄養制度到美國空軍，再到耶魯與劍橋求學的奮鬥歷程。他提出「奢侈信念」(luxury belief) 的觀念，揭示上層社會藉由炫耀進步思想來獲取地位，卻讓弱勢者承受代價。本書深刻描繪階級、家庭與身分的掙扎，令人動容。NATIONAL BESTSELLER In this "affecting...intriguing...heartbreaking" (Booklist) coming-of-age memoir, Rob Henderson vividly recounts growing up in foster care, enlisting in the US Air Force, attending elite universities, and pioneering the concept of "luxury beliefs"--ideas and opinions that confer status on the upper class while inflicting costs on the less fortunate. Rob Henderson was born to a drug-addicted mother and a father he never met, ultimately shuttling between ten different foster homes in California. When he was adopted into a loving family, he hoped that life would finally be stable and safe. But divorce, tragedy, poverty, and violence marked his adolescent and teen years, propelling Henderson to join the military upon completing high school. A "vivid, insightful, poignant, and powerful" (Nicholas A. Christakis, author of

Learn all about the fascinating world of insects--from bees, to butterflies, beetles, and more. Grab your magnifying glass and head out to discover all about insects-- their different types, body structures, and behaviors. Filled with eye-catching images and bite-sized information, every young nature enthusiast will marvel at the mind-boggling facts about these adaptable creatures. The book covers the seven major insect groups and includes profiles for more than 40 amazing insects, such as the stag beetle, monarch butterfly, and honeybee. Dive into their brilliant world and learn how some insects blend in with their surroundings. Discover how some can survive in different environments, while others can defend themselves against predators using clever tactics. Explore the many ways in which insects help humans, and the crucial role they play in pollination and maintaining a balance in the ecosystem. My Book of Bugs is a wonderful introduction to insects and their many incredible feature

Inside Scouts: An Acorn Book (Book1-3)The Inside Scouts Viv and Sanjay help a lion with a leaky heart in this full-color early reader series!Pick a book. Grow a Reader!This series is part of Scholastic's early reader line, Acorn, aimed at children who are learning to read. With easy-to-read text, a short-story format, plenty of humor, and full-color artwork on every page, these books will boost reading confidence and fluency. Acorn books plant a love of reading and help readers grow!Viv and Sanjay are the Inside Scouts! Together, they help animals. They have a cool superpower -- they can shrink super small. When a lion with a leaky heart needs help, the Inside Scouts know what to do! They put on their suits, grab their tools, and get really small. They go inside the lion to find the leaky spot. And they fix it together!This series introduces beginning readers to the human body through mammals with similar anatomy -- and it does so in really fun ways! In this first book, readers learn a

Oscar the Grouch meets Frog & Toad in this hilarious illustrated early reader series about a cranky wolf on a quest to be left alone. Wolf has just the right amount of friends: NONE. He loves to be alone. Unfortunately, everywhere he goes, other people are there too. At school, the teacher says if he can't get along with the other students, he has to leave. So he goes to the movies. More people! He tries the beach. No peace there, either. He flees to the remote peak of a mountain, and even there, someone comes along to bother him. Finally, Wolf hatches a plan. All these people arrive for a party at Wolf's house . . . while Wolf makes a quick exit. Move over, Elephant & Piggie! For readers who have had enough of the buddy duos, for kids who'd rather play by themselves--Wolf is the antihero you've been waiting for. Lone Wolf Goes to School is the first in a hilarious early reader series starring the completely lovable, chronically grumpy Wolf, a character who affirms kids who fly

Ursula finds confidence in seeing the world her own way in another innovative, flipped-format picture book from Caldecott Honoree and Geisel Award winner Corey R. Tabor.Ursula is a happy catfish, swimming through a shimmering river with weeds waving above and a sky full of scrumptious bugs below.Then one question turns her world upside down.Is left right? Is right wrong? Which way even is up?From the Caldecott Honor–winning creator of Mel Fell comes another innovative, flipped-format picture book that encourages children to find confidence in their individuality.