Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Minecraft 不只是遊戲，更是一個能動手思考的學習空間。本書從玩家熟悉的遊戲場景出發，介紹 redstone 方塊如何模擬現實世界中的電路與程式邏輯，讓讀者在建造機關與裝置的過程中，逐步理解編碼思維。內容著重於「怎麼想」而非死背指令，鼓勵讀者觀察、嘗試與修正。書中大量運用照片、示意圖與整理圖表，將抽象的程式概念轉化為可視化的操作流程，適合對科技、工程與創作有興趣的孩子閱讀。Introduced in 29, Minecraft™ has become an enormous success with gaming kids and adults. Users love exploring and building within Minecraft’s mind-bogglingly large environments. This game allows users to practice STEM skills while having fun. One of its greatest strengths is its ability to teach coding principles with “redstone” blocks. These blocks can be used to make exciting machines and devices in Minecraft’s virtual world. With this volume, readers will learn the logic and technology behind coding with Minecraft™. Photographs, diagrams, sidebars, and a graphic organizer help reinforce basic coding concepts.Minecraft is a trademark of Mojang (a game development studio owned by Microsoft Technology Corporation), and its use in this book does not imply a recommendation or endorsement of this titl

"The author provides unprecedented critical, interdisciplinary explorations of the complex dynamics and intersectionalities operating between disability and poverty in rural areas, an assumed relationship that is too often misunderstood. Reporting on long term ethnographic work in Guatemala and prioritising the voices, knowledge and narratives of disabled people and their families, Grech offers an incisive and refined critical analysis of the various complex barriers and interactions in the disability/poverty/rurality nexus encountered by what Grech calls 'disabled families'. The book opens up discussions on a broad range of themes traversing conceptual, spatial, historical, embodied, spiritual, racial, sexual and gendered terrains among others. It challenges and reframes established, often imposed discourses and practices, and contests issues of (re)presentation, Eurocentrism, and coloniality. Finally, it contributes new and uncharted reflections for further debate, which are indispen

An entertaining diary format based on this much-loved fairy tale, told from the perspective of the Ugly Duckling himself. Pop-ups bring the book to life, perfect for engaging early readers. Multi-medi

Here’s a beautiful historical fiction picture book—perfect for the Common Core—that provides a rare glimpse into the early childhood of Albert Einstein, the world’s most famous physicist. Three-year-o

Learn about the boys' pre-fame history, early hometown success, and their discovery on YouTube. Includes details on the band's relationship with friends and mentors One Direction, individual bios, doz

This book discusses how consultations with young children could signal a change of thinking about how children might influence policy and shape the development of a child-friendly state. While the con

The violent protests in Lhasa in 2008 against Chinese rule were met by disbelief and anger on the part of Chinese citizens and state authorities, perplexed by Tibetans’ apparent ingratitude for the ge

1885年11月，畫家莫內來到法國海邊小鎮度假，他天天攜畫具外出寫生，只為捕捉海岸的光影與變化。有天清晨，他畫得太入神，竟忘了注意漲潮……本書根據真實事件改編，透過細膩插圖與畫家筆記節錄，帶領讀者走進印象派大師的創作日常，感受他筆下的光與色。In November 1885, impressionist painter Claude Monet vacationed in Étretat, France, where he spent his days outside, painting scenes of the seaside village. One morning he rose early and carried all of his supplies and half-finished paintings out to the cliffs and rocky beach, finally stopping to paint the arch called Manneporte. Eager to capture the scene before him, and aware that he must work quickly to catch the light, Monet became so engrossed in his work that he forgot to watch the incoming tide. Based on a true incident, MONET PAINTS A DAY introduces readers to the life and nature of this illustrious impressionist. Interspersed throughout the story are excerpts from the painter’s notes and letters, while a second layer of text and back matter includes information about Impressionism as a whole. Lush watercolor illustrations in the Impressionist style give read

An entertaining diary format based on this much-loved fairy tale, told from the perspective of Cinderella herself. Pop-ups bring the book to life, perfect for engaging early readers. Multi-media illus

An entertaining diary format based on this much-loved fairy tale, told from the perspective of Jack himself. Pop-ups bring the book to life, perfect for engaging early readers. Multi-media illustratio

2012 Robert F. Sibert Medal Winner Winner of the 2012 NCTE Orbis Pictus Award Everyone’s a New Yorker on Thanksgiving Day, when young and old rise early to see what giant new balloons will fill the

Against the background of accelerating globalization and growing economic interdependence in Northeast Asia over the past two decades, including the recent global economic crisis, this book sets out t

本書譯自Bernard R. Glick及Jack J. Pasternak所著的《Molecular Biotechnology: Principles and Applications of Recombinant DNA》第3版，並由國內多位從事分子生物技術之專家、學者及教師所共同翻譯而成。本書素以觀念清晰、內容完善、解釋詳盡著稱，並一直受到許多教師的推薦與使用。本書中譯版的出版，希望能嘉惠

十三歲的小魔女琪琪依照傳統，離開家展開獨立生活。帶著會說話的黑貓吉吉，她來到海邊小鎮，開設空中宅急便。本書以電影原畫為插圖，搭配簡潔故事文字，重現琪琪初到異鄉、學會自立與重新找回魔法的歷程，是親子共讀的溫馨之選，也讓小讀者感受勇敢與成長的力量。Kiki, a young witch-in-training, has reached the age of 13. According to tradition, all witches of that age must leave home for one year, so that they can learn how to live on their own. Kiki, along with her talking cat Jiji, fly away to live in the seaside town of Korico. After starting her own delivery service (using her broom as the delivery vehicle), Kiki must learn how to deal with her new life, especially after she loses the power to fly.A breezy picture and story book featuring artwork taken directly from the movie, Kiki’s Delivery Service.

Praise for Winning At Retail "Winning at Retail offers the most effective strategies available for retailers. At McDonald's, the 'Quick-EST' model is crucial, because being close and convenient to where our customers live, work, and shop helps us create maximum value. If you want to harness your company's strengths to become a leader in your category-and stay in tune with what your customers want-this is the book for you." -Jim Rand, Senior Vice President of Business Development, McDonald's Corporation "Winning at Retail provides a thoughtful approach to retail differentiation. Ander and Stern warn of the 'treacherous middle' into which retailers too easily drift. They inspire us to avoid this peril through case studies of retailers who have assumed leadership through courageous choice." -Robert L. Price, Senior Vice President and Chief Marketing Officer, Wawa "In a difficult retail environment, this book provides crucial guidance for staying on top of your competition-by taking the cu

"Read it for no other reason than to learn Bob's Seven Immutable Laws of Business. . . . This is vintage Bob-contrarian, thoughtful, and he's really fun to read."—Forbes In this edition of Bob Lutz's bestselling account of the business philosophy with which he revolutionized Chrysler and much of the automotive industry, Lutz reveals his unique brand of creative management. Readers will learn many lessons herein, including why the key to success in any business is maintaining a positive tension between the creative minds and the buttoned-up financial minds, and how to attract, motivate, and strategically deploy each type throughout an organization. This book features a new introduction and an epilogue in which Lutz introduces an eighth law that helps today's business leaders put his famed Seven Immutable Laws of Business into sharper perspective. Robert A. Lutz (Scarsdale, NY) is General Motor's Vice Chairman of Product Development and Chairman of GM North America.

本書探討當代企業管理風格的轉變，特別是「避險」思維如何逐漸取代「冒險」精神。作者深入分析企業在法規限制、媒體監督與社會輿論壓力下，為何傾向保守決策，並指出這種趨勢可能削弱創新能力與技術發展動能。全書結合理論觀點與實際案例，反思企業如何在穩健與創新之間找到平衡。文字冷靜、分析透徹，是研究企業文化與創新策略的重要讀物。This book looks at changing managerial styles in business and the predominance of risk aversion behavior over risk taking behavior. The author explores the various reasons (regulation and media scrutiny among them) that corporations are becoming more timid and analyzes the consequences this could have on the future of innovation and technological development in the business future.

This book explores the issues of nation and modernity in China by focusing on the work of Zhou Zuoren (1885-1967), one of the most controversial of modern Chinese intellectuals and brother of the writ

When a spunky mouse invites a passing bird to see what's inside a People House, chaos ensues while beginning readers learn the names of 65 common household items—and that people are generally not pleased to find mice and birds in their houses! A super simple, delightfully silly introduction to objects around the home—from none other than Dr. Seuss!

本書係繼「新產品開發指南」暨「研究開發之管理」兩書後，另一本同系列之書。作者以其從事研究開發(R&D)有關工作四十年之經驗，就研發工作者的立場，闡明對研發工作的正確認識及應有作法：包括怎樣的研究開發會賺錢？不賺錢的研究怎麼辦？等的訣竅。為研發工作者暨經營幹部必讀！

This book describes in detail a research project dedicated to liquid-particle flow using ultrasound techniques. The project consists of theoretical, experimental, data science, finite element modeling, mechanical design and project management components. The objective of the project was to develop the ultrasonic methodology for measurement and characterization of liquid flow containing solid particles, in online (real-time) measurement conditions. The project consists of primary and complementary studies. The primary studies comprise development of the ultrasonic methodology for the simultaneous measurement of the average particle concentration and flow speed parameters. The developed methodology is based on the ultrasonic attenuation spectroscopy and the sound speed measurement methods, supported by data science programs. The complementary studies include acoustic streaming, designing a small-scale rotational test cell with an annular flow channel, testing it for various applications

Designed as a textbook for a one or two-term introduction to mathematical statistics for students training to become data scientists, Foundations of Statistics for Data Scientists: With R and Python is an in-depth presentation of the topics in statistical science with which any data scientist should be familiar, including probability distributions, descriptive and inferential statistical methods, and linear modelling. The book assumes knowledge of basic calculus, so the presentation can focus on 'why it works' as well as 'how to do it.' Compared to traditional "mathematical statistics" textbooks, however, the book has less emphasis on probability theory and more emphasis on using software to implement statistical methods and to conduct simulations to illustrate key concepts. All statistical analyses in the book use R software, with an appendix showing the same analyses with Python.The book also introduces modern topics that do not normally appear in mathematical statistics texts but ar

Introduction to Time Series Modeling: with Applications in R, Second Edition covers numerous stationary and nonstationary time series models and tools for estimating and utilizing them. The goal

In the global race to reach the end of AIDS, why is the world slipping off track? The answer has to do with stigma, money, and data. Global funding for AIDS response is declining. Tough choices must be made: some people will win and some will lose. Global aid agencies and governments use health data to make these choices. While aid agencies prioritize a shrinking list of countries, many governments deny that sex workers, men who have sex with men, drug users, and transgender people exist. Since no data is gathered about their needs, life-saving services are not funded, and the lack of data reinforces the denial. The Uncounted cracks open this and other data paradoxes through interviews with global health leaders and activists, ethnographic research, analysis of gaps in mathematical models, and the author's experience as an activist and senior official. It shows what is counted, what is not, and why empowering communities to gather their own data could be key to ending AIDS.

Practical Spreadsheet Modeling Using @Risk provides a guide of how to construct applied decision analysis models in spreadsheets. The focus is on the use of Monte Carlo simulation to provide quantitat

This book shows how to analyze spatial and spatial-temporal data. It focuses on key datasets and data analysis, using the open source software WinBUGS, R, and GeoDa. It examines a range of different s

Software Simulation and Modeling in Psychology: MATLAB, SPSS, Excel and E-Prime describes all the stages of psychology experimentation, from the manipulation of factors, to statistical analysis, data

Biophysical techniques are used in many key stages of the drug discovery process including in screening for new receptor ligands, in characterising drug mechanisms, and in validating data from biochem

Analyzing Health Data in R for SAS Users is aimed at helping health data analysts who use SAS accomplish some of the same tasks in R. It is targeted to public health students and professionals who hav

This text illustrates the application of calculus to biology and medicine using the example of mathematically modeling challenges in the Lake Victoria region. It uses real data to show how to model

Designing Experiments and Analyzing Data: A Model Comparison Perspective (3rd edition) offers an integrative conceptual framework for understanding experimental design and data analysis. Maxwell, Dela

This book discusses the application of Geospatial data, Geographic Information System (GIS) and Remote Sensing (RS) technologies in analysis and modeling of urban growth process, and its pattern,

Design and Analysis of Time Series Experiments presents the elements of statistical time series analysis while also addressing recent developments in research design and causal modeling. A distinguis

Drug Delivery Approaches and Nanosystems, Volume 2: Drug Targeting Aspects of Nanotechnology is a thorough presentation of the state-of-the-art research and developments in drug delivery systems using

The Early Formative Olmec are central in a wide variety of debates regarding the development of Mesoamerican societies. A fundamental issue in Olmec archaeology is the nature of interregional interaction among contemporaneous societies and the possible Olmec role in it. Previous debates have often not been informed by recent research and data, often relying on materials lacking archaeological context. In order to approach these issues from new perspectives, this book introduces readers to the full spectrum of the material culture of the Olmec and their contemporaries, relying primarily on archaeological data, much of which has not been previously published. For the first time, using a standard lexicon to consider the nature of the interaction among Early Formative societies, the authors, experts in diverse regions of Mesoamerican art and archaeology, provide carefully considered contrasts and comparisons that advance the understanding of the Early Formative origins of social complexity

This book presents a unified approach for modeling hydrologic processes distributed in space and time using geographic information systems (GIS). This Third Edition focuses on the principles of implem

A reference on drug metabolism and metabolite safety in the development phase, this book reviews the analytical techniques and experimental designs critical for metabolite studies. It features case st

This book presents the latest numerical solutions to initial value problems and boundary value problems described by ODEs and PDEs. The author offers practical methods that can be adapted to solve wide ranges of problems and illustrates them in the increasingly popular open source computer language R, allowing integration with more statistically based methods. The book begins with standard techniques, followed by an overview of 'high resolution' flux limiters and WENO to solve problems with solutions exhibiting high gradient phenomena. Meshless methods using radial basis functions are then discussed in the context of scattered data interpolation and the solution of PDEs on irregular grids. Three detailed case studies demonstrate how numerical methods can be used to tackle very different complex problems. With its focus on practical solutions to real-world problems, this book will be useful to students and practitioners in all areas of science and engineering, especially those using R.

Clinical pharmacology plays a vital role in drug development to ascertain how the drug affects the human subject. The aim of this book is to discuss some essential researches and advancements in this

Computational biology drives discovery through its use of high-throughput informatics approaches. This book provides a road map of the current drug development process and how computational biology approaches play a critical role across the entire drug discovery pipeline. Through the use of previously unpublished, real-life case studies the impact of a range of computational approaches are discussed at various phases of the pipeline. Additionally, a focus section provides innovative visualisation approaches, from both the drug discovery process as well as from other fields that utilise large datasets, recognising the increasing use of such technology. Serving the needs of early career and more experienced scientists, this up-to-date reference provides an essential introduction to the process and background of drug discovery, highlighting how computational researchers can contribute to that pipeline.