Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

"Applaud for KLAWDE. Two paws up!"--Dav Pilkey, creator of the Dog Man series.Klawde is not your average cat. He's an emperor from another planet, exiled to Earth. He's cruel. He's cunning. He's brilliant... and he's about to become Raj Banerjee's best friend. Whether he likes it or not.Klawde had everything. Sharp claws. Fine fur. And, being the High Commander of the planet Lyttyrboks, an entire world of warlike cats at his command. But when he is stripped of his feline throne, he is sentenced to the worst possible punishment: exile to a small planet in a quiet corner of the universe... named Earth. Raj had everything. A cool apartment in Brooklyn. Three friends who lived in his building. And pizza and comics within walking distance. But when his mom gets a job in Elba, Oregon, and he is forced to move, all of that changes. It's now the beginning of summer, he has no friends, and because of his mother's urgings, he has joined a nature camp.It's only when his doorbell rings and he meet

"Applaud for KLAWDE. Two paws up!"--Dav Pilkey, creator of the Dog Man series.Klawde is not your basic cat. He's an emperor from another planet, exiled to Earth. He's cruel. He's cunning. He's brilliant... and he's also Raj Banerjee's best friend.Klawde and Raj are back! As summer turns to fall, our favorite warlord cat remains in his pitiful exiled existence. But Raj has an even scarier prospect than cosmic exile: starting at a new school. And if things didn't seem complicated enough, both cat and human are confronted with two figures from their past they did not expect to pop up in Elba, Oregon...Heavily illustrated, with a hilarious, biting voice that switches between Raj's and Klawde's perspectives, this is the story of an unlikely friendship that emerges as two fish out of water continue to find their footing in strange new worlds.

This work offers the most comprehensive account of the origin and consequences of the Yan’an Rectification Movement from 1942 to 1945. The author argues that this campaign emancipated the Chinese Comm

See the human body as never before, in this unique scratch and discover format. Every spread addresses a new theme, teaching little ones about about our skeletons, muscles and brains! An appealing, in

Three hundred years ago, fate bound Prosper Redding and Prince Alastor of the Third Realm together. Now the human boy and fiend heir to the demon kingdom must put aside a centuries-old blood feud to save everything they love. Alastor will guide Prosper through the demon realm-under one huge condition: Prosper must enter into a contract with the malefactor residing in him, promising eternal servitude in the afterlife. With Prosper's sister in the clutches of the evil queen Pyra, Prosper has no choice but to agree. But when they arrive in Alastor's deliciously demonic home, the realm is almost as alien to Alastor as it is to Prosper-the lowest fiends have dethroned the ruling malefactors, while an unfathomable force called the Void is swiftly consuming the realm. The desperate fiends cling to the one person who says she can stop it: Pyra. As Prosper embarks on a perilous rescue mission to the Tower of No Return, he can't help but feel for the demons losing their home-even Alastor, who li

New in the Little People, Big Dreams series, discover the life of Muhammad Ali, 'the greatest' boxer of all time, in this true story of his life. As a child, young Cassius Clay had his bike stolen. He

Heave ho! Set sail on a high-seas adventure with swashbuckling pirates in search of treasure in this new MagnetologyTM title. Kids can use the forty-five magnetic pieces included to fill five dramatic

The publication of this book marks the fifteenth anniversary of the outbreak of SARS epidemic in Hong Kong in 2003. This documentary study, originating as a research project a year after the epidemic,

The Crown Jewels are in danger... again! When the jewels go missing from inside a locked room, Mac's spy skills are put to the test. How did the thief break in? Where did the jewels go? And will Mac b

In their analyses of the role of women in politics, political scientists had tended to neglect the family and the labour market, thus ignoring a crucial aspect of women's political activity. Originall

A game of hide-and-seek in the forest might lead to unexpected discoveries. Could there be something hidden in the trees?When their dog goes missing, siblings Poppy and Cy decide to play hide-and-seek

Imagine a human society, perhaps in pre-history, in which people were generally of a psychological kind with us, had the use of natural language to communicate with one another, but did not have any p

Did you know there are over 47,000 facts in the world?* And the good news is, many of them are in this book. That’s right, The Grand Tour A-Z of the Car is the only reference guide you need for cars,

A groundbreaking graphic novel-style cocktail book from world-renowned bar The Dead Rabbit in New York City The Dead Rabbit Grocery & Grog in lower Manhattan has won every cocktail awa

Join two unlikely friends (and one cleverly hidden ladybug), as they discover that anything is possible when you believe in yourself - and each other.When a potted houseplant is placed down in a room

Join your favorite Disney characters for six bedtime stories in one soft, snuggly book.

Born into a Jewish family in Frankfurt, Germany, in 1929, Anne Frank was only thirteen years old when her family went into hiding to escape persecution during the Holocaust. Anne kept a diary detailin

A foolish knight is certain that his side of the wall is the safe side in this clever, amusingly meta picture book by the acclaimed creator of It's Only StanleyThere's a wall in the middle of the book

Best friends Little Elliot and Mouse go looking for Christmas spirit in this winter holiday picture book.

Journey back through childhood classics like Peter Pan, Alice's Adventures in Wonderland, and more in this adorable picture book about the joys of reading!There is nothing like a book to take you to p

On a crisp autumn day Mouse and Minka celebrate fall by jumping in a pile of leaves in this adorable Pre-Level 1 Ready-to-Read book about fall!One cool fall day, Mouse and Minka come out to play! They

Christina Rossetti (1830-94) is regarded is one of the greatest Christian poets to write in English. While Rossetti has firmly secured her place in the canon, her religious poetry was for a long time

This playful preschool activity book will unleash your child's curiosity and creativity as they play their way through amazing STEM projects.Perfect for kids ages 3-6, this early learning children's book will excite little ones by revealing the everyday ways they can be an engineer. Children are born with everything they need to be great engineers: inquisitive minds, unlimited imagination, and super senses. With Look I'm an Engineer, little readers are encouraged to use their senses to investigate how to make the strongest paper bridges, how to power a tugboat with an elastic band, which materials make the best parachutes, and much more. Every fun project features a mixture of bright photography and charming illustrations which support the easy-to-follow activity instructions. These wonderful hands-on activities align with subjects taught at school, including science, math, and technology. Little ones have the opportunity to do what they do best: imagine, create, learn, problem solve,

New in the Little People, Big Dreams series, discover the incredible life of Mother Teresa, in this true story of her life. With stylish and quirky illustrations and extra facts at the back, this empo

New in the Little People, Big Dreams series, discover the life of Anne Frank, the writer whose diary captured the hearts of the public, in this true story of her life. Little Anne was born in Germany

There is no single masterpiece in art galleries or with people—we’re all works of art in our own special way! Our skin tones might all vary;we're every shade and hue.Some people think we look surreal,

New in the Little People, Big Dreams series, discover the life of Anne Frank, the writer whose diary captured the hearts of the public, in this true story of her life. Little Anne was born in Ger

This guidebook is for college instructors who teach a course in Introduction to Logic at a teachers college or provide a workshop in this subject for in-service mathematics teachers. It can also be us

Autumn leaves aren’t the only things falling in the historic Virginia village of Taylorsford—so are some cherished memories, and a few bodies. October in Taylorsford, Virginia means it’s leaf peeping

Children all over the world are very different, but they also have much in common. In this beautifully illustrated book, young children can learn all about what people in other countries eat, wear and

The first woman to fly solo across the Atlantic Ocean, Amelia Earhart was a superstar of aviation in the 1920s and 1930s and a pioneer of women's rights. Her disappearance in 1937, while attempting to

The Origins of a Legendary PhotographerAnnie Leibovitz's photographic breakthrough and Rolling Stone reportageFor more than half a century, Annie Leibovitz has been taking culture-defining photographs

In this sequel to the New York Times bestseller 99 Days, perfect for fans of Jenny Han and Morgan Matson, Molly Barlow finds herself in Europe on her summer vacation, desperately trying to forget ever

In this modern fairy tale, a noble prince and a brave knight come together to defeat a terrible monster and in the process find true love in a most unexpected place.“Thank you,” he told hi

The formerly glorious god Apollo, cast down to earth in punishment by Zeus, is now an awkward mortal teenager named Lester Papadopoulos. In order to regain his place on Mount Olympus, Lester must rest

In celebration of the arrival of the fifth in line to the throne, ‘Royal Babies – A Heir-Raising History’ goes behind Palace doors to discover the pleasures, pain and pitfalls of Royal pregnancies, bi

Is a lion still a lion if he wears a hat? With whimsical illustrations and a nod to earlier classics, Polly Dunbar celebrates the shrewd mind of a child — and the power of saying no.Is a lion still a lion . . . if he skips down the street singing "Hoobie-doobie-doo"?Dapper in his hat and flourishing a cane, a very large lion invites himself inside, inquires about Auntie Sue, and spins the two children of the house around the room in a silly dance. He doesn’t mind at all if they invite him to lunch, where he gobbles up all his greens and devours the plate, too. When he leans in to ask for dessert, his sharp teeth gleam oh so pearly white, and it seems very possible that he may just bite. . . . Surely it’s time to go-go-go — until, that is, the brave little girl finds her voice in a most satisfying way. The Cat in the Hat meets Pierre meets The Tiger Who Came to Tea in this rollicking story with an exhilarating ending.

New from the creator of Skunk on a String comes Wallpaper, a wordless picture book in Thao Lam’s signature paper collage style. It tells the story of a young girl whose family moves into a new house. Outside, she can hear other kids playing, but she’s too shy to say hello. So she picks at the old wallpaper in her room—revealing an entryway to a fantastic imaginary adventure world behind the walls.There, she runs between the vibrant and varied environments—surrounded by birds, swimming in a frog pond, in a herd of art-deco sheep—as she finds herself chased by a monster. He is frightening at first, until it becomes clear he simply wants to be her friend. When it comes time to go back to reality, the girl feels inspired with the courage to approach the other kids and say hello.Full of humor and heart, this book delivers exquisite illustrations in a lively fantasy narrative that will inspire thinking about bravery and overcoming obstacles.

Sunny tries to shine despite his troubled past in this third novel in the critically acclaimed Track series from National Book Award finalist Jason Reynolds.Ghost. Patina. Sunny. Lu. Four kids from wi

In this romantic dramedy from the author of Alex, Approximately, a teen girl’s way-too-ordinary life is driven off the beaten path when she’s abandoned in the wilderness with her worst adv