Bioreaction Engineering Principles

Uniquely focusing on dynamic modeling, this volume incorporates metabolic regulation as a survival mechanism for cells, by driving metabolism through optimal investment of its resources for control of enzyme synthesis and activity. Consequently, the models have a proven record of describing various uptake patterns of mixed carbon substrates that have become significant in modern applications of biomass for the production of bioenergy. The models accurately describe dynamic behavior of microbes in nutrient environments with mixtures of complementary substrates, such as carbon and nitrogen. Modeling of large metabolic networks (including prospects for extension to genome scale) is enabled by lumped hybrid cybernetic models with an unparalleled capacity to predict dynamic behavior of knockout strains. This is an invaluable, must-have reference for bio-researchers and practicing engineers.

The present text is a complete revision of the 2nd edition from 2003 of the book with the same title. In recognition of the fast pace at which biotechnology is moving we have rewritten several chapter

Volume 3 of Bioreaction Engineering covers the general principles and techniques of bioprocess monitoring and their application for various bioprocesses. Methods based on the author's long standing ex