Dopamine

Dopamine, a catecholamine transmitter, plays a number of vital physiological roles in the brain and body, and, in recent years, studies on the role of dopamine in disease have opened new avenues of re

Since its discovery 50 years ago, brain dopamine has been implicated in the control of movement and cognition, and is concerned with diverse brain diseases such as Parkinson's disease, schizophrenia and drug addiction. This book is an illustrated biography of the dopamine molecule, from its synthesis in the brain to its signalling mechanisms and ultimately to its metabolic breakdown. Using colour illustrations of positron emission tomography (PET) scans, each chapter presents a specific stage in the biochemical pathway for dopamine. Writing for researchers and graduate students, Paul Cumming presents a compilation of all that has been learned about dopamine through molecular imaging, a technology which allows the measurement of formerly invisible processes in the living brain. He reviews current technical controversies in the interpretation of dopamine imaging, and presents key results illuminating brain dopamine in illness and health.

INSTANTNEW YORK TIMESandLOS ANGELES TIMESBESTSELLER“Brilliant . . . riveting, scary, cogent, and cleverly argued.”—Beth Macy, author ofDopesickThis book is about pleasure. It’s also about pain. Most important, it’s about how to find the delicate balance between the two, and why now more than ever finding balance is essential. We’re living in a time of unprecedented access to high-reward, high-dopamine stimuli: drugs, food, news, gambling, shopping, gaming, texting, sexting, Facebooking, Instagramming, YouTubing, tweeting . . . The increased numbers, variety, and potency is staggering. The smartphone is the modern-day hypodermic needle, delivering digital dopamine 24/7 for a wired generation. As such we’ve all become vulnerable to compulsive overconsumption.InDopamine Nation, Dr. Anna Lembke, psychiatrist and author, explores the exciting new scientific discoveries that explain why the relentless pursuit of pleasure leads to pain . . . and what to do about it. Condensing complex neurosc

The discovery of dopamine in 1957-1958 was one of the seminal events in the development of modern neuroscience, and has been extremely important for the development of modern therapies of neurologica

As sites of action for drugs used to treat schizophrenia and Parkinson’s disease, dopamine receptors are among the most validated drug targets for neuropsychiatric disorders. Dopamine receptors are al

To foster a better understanding of dopamine receptor functionality, this detailed volume creates an interface between updated classical methods and new emerging technologies heretofore not available

Progress in Brain Research is a well-established international series examining major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume

The neurotransmitter dopamine has just celebrated its 50th birthday. The discoveryof dopamine as a neuronal entity in the late 1950's and the notion that it servesin neurotransmission has been a mile

Understanding the dopamine transporter can lead to new therapies for neurological disorders This book consolidates current information on the dopamine transporter (DAT) in relationto medicinal chemis

Parkinson's disease becomes apparent only after substantial loss (>60%) of the dopamine neurons in the substantia nigra. By this time there has already been widespread neural inclusion formation in th

This book offers a comprehensive but highly readable compilation of papers on the role of dopamine in sleep and sleep disorders. Leading experts in sleep medicine, psychiatry and neuroendocrinology pr

This book provides a unique and timely multidisciplinary synthesis of our current knowledge of the anatomy, pharmacology, physiology and behavioral data of the serotonin (5-HT)-dopamine (DA) interacti

'Details the function, characterization, and physiology of various dopamine receptor/transporter systems and explores their role in etiology, diagnosis, and disease management.'

Since its discovery in the 1960s, a vast and wide-ranging body of research has accumulated about the dopaminergic system. Life's Rewards: Linking Dopamine, Incentive Learning, Schizophrenia, and the M

FROM THE BOOKER PRIZE-WINING AUTHOR OF VERNON GOD LITTLE'Pierre's high-risk prose explores and expands the cartoonish, taboo-busting outer edges of literary possibility.' -- Independent***It's a big bad world out there, in Dopamine City. All Lonnie Cush wants is to keep his kids safe. But Shelby-Ann - his little girl, the maddening apple of his eye - has other ideas: Shelby-Ann wants her first smartphone.So new realities are rocketing their way to 37 Palisade Row, where everything will change, every day, and at mortal speed. Until Lonnie finds himself in a stitch: he'll have to join this new world, or wither in it. Or can he mastermind a vanishing act?The story of a hapless father's love and loss, and a speedball, starburst satire, Meanwhile in Dopamine City is a passionate, freewheeling work from the winner of the Booker Prize: a riotous cry for the soul and the flesh and the heart in the cooling bathwater of our automatic times.

It's a big bad world out there in twenty-first century Dopamine City. Modern life has taken its toll on all Lonnie held dear. It took his young wife, then his job in the sewers. Now it has come for hi