Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Sustainable development remains a high priority in international politics and commerce. This timely book explores how the contours and facets of economic, environmental and social sustainability are r

This book addresses the teaching and cultural activities of the Akademia Zamojska in the Early Modern Age. The main subject is the development of politics as a university discipline in this school and

The methods and techniques presented in this book are focused on spatial data and its use in monitoring agricultural resources, farm management, and regional markets. Spatial econometrics models are i

Since the early 2000s, corporate social responsibility (CSR) has rapidly gained significance in India, both among large companies and as a policy instrument formally intended to foster corporate contributions to the country's development goals. This book analyses this phenomenon in relation to broader political and economic changes induced by India's 'pro-business' development strategy. Using a systems-theoretical approach, the analysis shows that 'pro-business' policies have led profit-driven economic processes to increasingly override collective aspirations for social welfare, environmental protection, and democracy. In order to decipher how CSR changes the interplays between profit-making and developmental aspirations, the book provides detailed analyses of CSR in the cement industry and in regulatory policies adopted by the central government. It shows that CSR operates as an 'intermediary institution' which further enhances the autonomy of the economic system, as it makes profit-m

Completely updated with the latest research in child development and learning, Positive Discipline for Preschoolers will help parents understand their preschooler and provide early methods to raise a

Blender (TM) is a free Open Source 3D Creation Suite supporting the entire modeling and animation pipeline - modeling, rigging, animation, simulation, rendering, compositing and motion tracking. The p

An overview of the optical effects in solids, addressing the physics of various materials and their response to electromagnetic radiation. The discussion includes metals, semiconductors, superconductors, and insulators. The book begins by introducing the dielectric function into Maxwell's macroscopic equations and finding their plane-wave solution. The physics governing the dielectric function of various materials is then covered, both classically and using basic quantum mechanics. Advanced topics covered include interacting electrons, the anomalous skin effect, anisotropy, magneto-optics, and inhomogeneous materials. Each subject begins with a connection to the basic physics of the particular solid, after which the measurable optical quantities are derived. It allows the reader to connect measurements (reflectance, optical conductivity and dielectric function) with the underlying physics of solids. Methods of analysing experimental data are addressed, making this an ideal resource for

In this new early chapter book in the popular Confetti Kids series, Pablo is excited to help his friends find the best route to Coney Island by using different transportation maps.Five friends from di

Methods and perspectives to model and measure productivity and efficiency have made a number of important advances in the last decade. Using the standard and innovative formulations of the theory and practice of efficiency and productivity measurement, Robin C. Sickles and Valentin Zelenyuk provide a comprehensive approach to productivity and efficiency analysis, covering its theoretical underpinnings and its empirical implementation, paying particular attention to the implications of neoclassical economic theory. A distinct feature of the book is that it presents a wide array of theoretical and empirical methods utilized by researchers and practitioners who study productivity issues. An accompanying website includes methods, programming codes that can be used with widely available software like MATLAB® and R, and test data for many of the productivity and efficiency estimators discussed in the book. It will be valuable to upper-level undergraduates, graduate students, and professional

Methods and perspectives to model and measure productivity and efficiency have made a number of important advances in the last decade. Using the standard and innovative formulations of the theory and practice of efficiency and productivity measurement, Robin C. Sickles and Valentin Zelenyuk provide a comprehensive approach to productivity and efficiency analysis, covering its theoretical underpinnings and its empirical implementation, paying particular attention to the implications of neoclassical economic theory. A distinct feature of the book is that it presents a wide array of theoretical and empirical methods utilized by researchers and practitioners who study productivity issues. An accompanying website includes methods, programming codes that can be used with widely available software like MATLAB® and R, and test data for many of the productivity and efficiency estimators discussed in the book. It will be valuable to upper-level undergraduates, graduate students, and professional

This volume will assist readers in fitting big data analysis into their service-based organizations.Volume I of this two-volume series focuses on the role of big data in service delivery systems. It d

In Experiments with Empire Justin Izzo examines how twentieth-century writers, artists, and anthropologists from France, West Africa, and the Caribbean experimented with ethnography and fiction in ord

This open access book focuses on trends in educational inequality using twenty years of grade 8 student data collected from 13 education systems by the IEA’s Trends in Mathematics and Science Study (T

This text closely examines ideas, analysis, and implementation details of data structures as a specialised topic in applied algorithms. It looks at efficient ways to realise query and update operations on sets of numbers, intervals, or strings by various data structures, including: search trees; structures for sets of intervals or piece-wise constant functions; orthogonal range search structures; heaps; union-find structures; dynamization and persistence of structures; structures for strings; and hash tables. Instead of relegating data structures to trivial material used to illustrate object-oriented programming methodology, this is the first volume to show data structures as a crucial algorithmic topic. Numerous code examples in C and more than 500 references make Advanced Data Structures an indispensable text.

Using the most recent prison and jail suicide data the second edition of Suicide and Self-Harm in Prisons and Jails explores how the stress associated with arrest, sentencing, and incarceration can co

Carbon Nanomaterials: Modeling, Design, and Applications provides an in-depth review and analysis of the most important carbon nanomaterials, including fullerenes, carbon nanotubes, graphene and novel

What every neuroscientist should know about the mathematical modeling of excitable cells. Combining empirical physiology and nonlinear dynamics, this text provides an introduction to the simulation and modeling of dynamic phenomena in cell biology and neuroscience. It introduces mathematical modeling techniques alongside cellular electrophysiology. Topics include membrane transport and diffusion, the biophysics of excitable membranes, the gating of voltage and ligand-gated ion channels, intracellular calcium signalling, and electrical bursting in neurons and other excitable cell types. It introduces mathematical modeling techniques such as ordinary differential equations, phase plane, and bifurcation analysis of single-compartment neuron models. With analytical and computational problem sets, this book is suitable for life sciences majors, in biology to neuroscience, with one year of calculus, as well as graduate students looking for a primer on membrane excitability and calcium signal

Reflecting a sea change in how empirical research has been conducted over the past three decades, Foundations of Agnostic Statistics presents an innovative treatment of modern statistical theory for the social and health sciences. This book develops the fundamentals of what the authors call agnostic statistics, which considers what can be learned about the world without assuming that there exists a simple generative model that can be known to be true. Aronow and Miller provide the foundations for statistical inference for researchers unwilling to make assumptions beyond what they or their audience would find credible. Building from first principles, the book covers topics including estimation theory, regression, maximum likelihood, missing data, and causal inference. Using these principles, readers will be able to formally articulate their targets of inquiry, distinguish substantive assumptions from statistical assumptions, and ultimately engage in cutting-edge quantitative empirical r

Humanities and Social Science (HASS) education is integral in the development of active and informed citizens, and encourages learners to think critically, solve problems and adapt to change. Making Humanities and Social Sciences Come Alive: Early Years and Primary Education prepares pre-service educators to become high quality HASS educators who can unlock the potential of all students. Closely aligned with the Australian Curriculum and Early Years Learning Framework, this text is designed to enhance teaching practices in history, geography, economics and business, and civics and citizenship. The text provides readers with an in-depth understanding of the curriculum structure, the individual disciplines, pedagogical approaches to teaching HASS, inclusivity, global connections and the transition to practice. Examples are provided for early childhood and primary education, making this an inclusive, versatile and comprehensive text. This book is an invaluable resource that provides pre-s

Reflecting a sea change in how empirical research has been conducted over the past three decades, Foundations of Agnostic Statistics presents an innovative treatment of modern statistical theory for the social and health sciences. This book develops the fundamentals of what the authors call agnostic statistics, which considers what can be learned about the world without assuming that there exists a simple generative model that can be known to be true. Aronow and Miller provide the foundations for statistical inference for researchers unwilling to make assumptions beyond what they or their audience would find credible. Building from first principles, the book covers topics including estimation theory, regression, maximum likelihood, missing data, and causal inference. Using these principles, readers will be able to formally articulate their targets of inquiry, distinguish substantive assumptions from statistical assumptions, and ultimately engage in cutting-edge quantitative empirical r

Despite novel approaches to the study of Early Christianity – New Historicity, New Philology, Gender and Queer Studies; many turns – Material, Linguistic, Cultural; and developments in Reception History, Cultural Transfer, and Entangled History, much scholarship on this topic differs little from that written a century ago. In this study, Markus Vinzent challenges the interpretation of the sources that have been used in the study of the Early Christian era. He brings a new approach to the topic by reading history backwards. Applying this methodology to four case studies, and using a range of media, he poses radically new questions on the famous 'Abercius' inscription, on the first extant apologist Aristides of Athens, on the prolific Hippolytus of Rome, and on Ignatius and the first non-canonical collection of letters. Vinzent's novel methodology of a retrospective writing thus challenges many fundamental and anachronistic assumptions about Early Christian history.

Stanley Milgram's obedience experiments are among the most influential and controversial scientific studies ever conducted. The experiments are commonly understood to have shown how easily people can be led into harming another person, simply as a result of following orders. Recently, however, Milgram's studies have been subjected to a sustained critique and re-evaluation. This book draws on the vast stock of audio recordings from Milgram's experiments to reveal how these experiments can be understood as occasions for argumentation and rhetoric, rather than showing how passive subjects can be led into simply doing as they are told. In doing so, it reconsiders what we understand by 'obedience' and extends how social psychologists have understood rhetoric itself.

Interest in nonparametric methodology has grown considerably over the past few decades, stemming in part from vast improvements in computer hardware and the availability of new software that allows practitioners to take full advantage of these numerically intensive methods. This book is written for advanced undergraduate students, intermediate graduate students, and faculty, and provides a complete teaching and learning course at a more accessible level of theoretical rigor than Racine's earlier book co-authored with Qi Li, Nonparametric Econometrics: Theory and Practice (2007). The open source R platform for statistical computing and graphics is used throughout in conjunction with the R package np. Recent developments in reproducible research is emphasized throughout with appendices devoted to helping the reader get up to speed with R, R Markdown, TeX and Git.

This is the most in-depth analysis of inequality and social polarization ever attempted for a preindustrial society. Using data from the archives of the Venetian Terraferma, and compared with information available for elsewhere in Europe, Guido Alfani and Matteo Di Tullio demonstrate that the rise of the fiscal-military state served to increase economic inequality in the early modern period. Preindustrial fiscal systems tended to be regressive in nature, and increased post-tax inequality compared to pre-tax - in contrast to what we would assume is the case in contemporary societies. This led to greater and greater disparities in wealth, which were made worse still as taxes were collected almost entirely to fund war and defence rather than social welfare. Though focused on Old Regime Europe, Alfani and Di Tullio's findings speak to contemporary debates about the roots of inequality and social stratification.

A textbook for learning 3d modeling fundamentals, this step-by-step lesson book develops the readers modeling skills through a series of modeling exercises creating modules for a medieval castle envir

A textbook for learning 3d modeling fundamentals, this step-by-step lesson book develops the readers modeling skills through a series of modeling exercises creating modules for a medieval castle envir

Carry out data analysis with PySpark SQL, graphframes, and graph data processing using a problem-solution approach. This book provides solutions to problems related to dataframes, data manipulation su

Get outside and do some fun science experiments! From making a rain guage to tracking clouds, making a sundial and catching snowflakes, these simple activities are quick and easy to do, using easily f

Get outside and do some fun science experiments! From making a raft and an ice sculpture to painting with water and testing materials, these simple activities are quick and easy to do, using easily fo

In the warped world of prescription drug pricing, generic drugs can cost more than branded ones, old drugs can be relaunched at astronomical prices, and low-cost options are shut out of the market. In Drugs, Money and Secret Handshakes, Robin Feldman shines a light into the dark corners of the pharmaceutical industry to expose a web of shadowy deals in which higher-priced drugs receive favorable treatment and patients are channeled toward the most expensive medicines. At the center of this web are the highly secretive middle players who establish coverage levels for patients and negotiate with drug companies. By offering lucrative payments to these middle players (as well as to doctors and hospitals), drug companies ensure that inexpensive drugs never gain traction. This system of perverse incentives has delivered the kind of exorbitant drug prices - and profits - that everyone loves except for those who pay the bills.

Transform your approach to oprisk modelling with a proven, non-statistical methodology Operational Risk Modeling in Financial Services provides risk professionals with a forward-looking approach to ri

In this volume, Joshua Eckhardt examines the religious texts and books that surrounded the poems, sermons, and inscriptions of the early modern poet and preacher John Donne. Focusing on the material r

Time-series analysis is used to identify and quantify periodic features in datasets and has many applications across the geosciences, from analysing weather data, to solid-Earth geophysical modelling. This intuitive introduction provides a practical 'how-to' guide to basic Fourier theory, with a particular focus on Earth system applications. The book starts with a discussion of statistical correlation, before introducing Fourier series and building to the fast Fourier transform (FFT) and related periodogram techniques. The theory is illustrated with numerous worked examples using R datasets, from Milankovitch orbital-forcing cycles to tidal harmonics and exoplanet orbital periods. These examples highlight the key concepts and encourage readers to investigate more advanced time-series techniques. The book concludes with a consideration of statistical effect size and significance. This useful book is ideal for graduate students and researchers in the Earth system sciences who are looking

Stockley’s Drug Interactions, edited by Claire L Preston, remains the world’s most comprehensive and authoritative international reference book on drug interactions. Based upon thousands of published

Time-series analysis is used to identify and quantify periodic features in datasets and has many applications across the geosciences, from analysing weather data, to solid-Earth geophysical modelling. This intuitive introduction provides a practical 'how-to' guide to basic Fourier theory, with a particular focus on Earth system applications. The book starts with a discussion of statistical correlation, before introducing Fourier series and building to the fast Fourier transform (FFT) and related periodogram techniques. The theory is illustrated with numerous worked examples using R datasets, from Milankovitch orbital-forcing cycles to tidal harmonics and exoplanet orbital periods. These examples highlight the key concepts and encourage readers to investigate more advanced time-series techniques. The book concludes with a consideration of statistical effect size and significance. This useful book is ideal for graduate students and researchers in the Earth system sciences who are looking

AN ESSENTIAL GUIDE TO USING BLOCKCHAIN TO PROVIDE FLEXIBILITY, COST-SAVINGS, AND SECURITY TO DATA MANAGEMENT, DATA ANALYSIS, AND INFORMATION SHARINGBlockchain for Distributed Systems Security con

The essential textbook on agent-based modeling—now fully updated and expandedAgent-Based and Individual-Based Modeling has become the standard textbook on the subject for classroom use and self-instru

Born in 1867, French Postimpressionist artist Pierre Bonnard was, with Henri Matisse, one of the greatest colorists of the early 20th century. As a painter, he preferred to work from memory, using dra

The essential textbook on agent-based modeling—now fully updated and expandedAgent-Based and Individual-Based Modeling has become the standard textbook on the subject for classroom use and self-instru

Deformation Based Processing of Materials: Behavior, Performance, Modeling and Control focuses on deformation based process behaviors and process performance in terms of the quality of the needed shap