Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Brilliantly evoking the long-vanished world of masters and servants portrayed in Downton Abbey and Upstairs, Downstairs, Margaret Powell’s classic memoir of her time in service, Below Stairs, is the r

BESTSELLING AUTHORS GO HOLMES—IN AN IRRESISTIBLE NEW COLLECTION edited by award-winning Sherlockians Laurie R. King and Leslie S. Klinger?Neil Gaiman. Laura Lippman. Lee Child. These are just three of

The year is 2054, and life has been reduced to a data feed. The fusing of virtual reality and cybernetics has ushered in the era of the surrogate, a new technology that lets users interact with the wo

Unlock Pathway Codes, Reshape Cancer FightProfessor BENJAMIN YAT-MING YUNG, former Professor in the Department of Pharmacology at Chang Gung University College of Medicine, draws on forty years of accumulated research on NPM1/B23 to present the world's first network model of cancer drug resistance and recurrence pathways.This book breaks free from traditional therapy frameworks, delving into the four major characteristics of cancer to reveal the core pathogenesis of nucleolar imbalance and analyze the regulatory mechanisms of seven key pathway categories. The breakthrough QGCT® deconstructs personalized dysregulated pathways for patients, while providing pathway-based supplement applications and clinical solutions.More than just a popular science introduction to cancer knowledge, it offers patients new directions in precision treatment and provides scientific prevention strategies for health-conscious individuals. By integrating cutting-edge science with personalized care, it transform

Dante’sInfernomeetsSusanna Clarke’sPiranesiin this all-new dark academia fantasyfrom R. F. Kuang, the #1New York Timesbestselling author ofBabel and Yellowface,in which two graduate students must put aside their rivalry and journey to Hell to save their professor’s soul—perhaps at the cost of their own.Katabasis, noun, Ancient Greek:The story of a hero’s descent to the underworldAlice Law has only ever had one goal: to become one of the brightest minds in the field of Magick. She has sacrificed everything to make that a reality: her pride, her health, her love life, and most definitely her sanity. All to work with Professor Jacob Grimes at Cambridge, the greatest magician in the world.That is, until he dies in a magical accident that could possibly be her fault.Grimes is now in Hell, and she’s going in after him. Because his recommendation could hold her very future in his now incorporeal hands and even death is not going to stop the pursuit of her dreams….Nor will the fact that her ri

A love letter to books, showing how many elements and people contribute to making something beautiful, from Caldecott honoree Elisha Cooper In this poetic and beautifully illustrated ode to creativity and the process of making books, Caldecott honoree Elisha Cooper takes readers on a journey showing how words and art move from one person to another. From writer to reader, and everyone who contributes in between: Here is a book, made with love. An artist's studio overflows with sketches, drafts, a wastebasket, and wonder. A publisher's office hums with computers, layouts, coffee, and teamwork. A printer makes a layout into a book using presses, ink, paper, and time. And that book travels to a school, to a library, to a student, to a home.

《Troubled》是一本動人且引人深思的回憶錄，講述Rob Henderson從破碎家庭、寄養制度到美國空軍，再到耶魯與劍橋求學的奮鬥歷程。他提出「奢侈信念」(luxury belief) 的觀念，揭示上層社會藉由炫耀進步思想來獲取地位，卻讓弱勢者承受代價。本書深刻描繪階級、家庭與身分的掙扎，令人動容。NATIONAL BESTSELLER In this "affecting...intriguing...heartbreaking" (Booklist) coming-of-age memoir, Rob Henderson vividly recounts growing up in foster care, enlisting in the US Air Force, attending elite universities, and pioneering the concept of "luxury beliefs"--ideas and opinions that confer status on the upper class while inflicting costs on the less fortunate. Rob Henderson was born to a drug-addicted mother and a father he never met, ultimately shuttling between ten different foster homes in California. When he was adopted into a loving family, he hoped that life would finally be stable and safe. But divorce, tragedy, poverty, and violence marked his adolescent and teen years, propelling Henderson to join the military upon completing high school. A "vivid, insightful, poignant, and powerful" (Nicholas A. Christakis, author of

Learn all about the fascinating world of insects--from bees, to butterflies, beetles, and more. Grab your magnifying glass and head out to discover all about insects-- their different types, body structures, and behaviors. Filled with eye-catching images and bite-sized information, every young nature enthusiast will marvel at the mind-boggling facts about these adaptable creatures. The book covers the seven major insect groups and includes profiles for more than 40 amazing insects, such as the stag beetle, monarch butterfly, and honeybee. Dive into their brilliant world and learn how some insects blend in with their surroundings. Discover how some can survive in different environments, while others can defend themselves against predators using clever tactics. Explore the many ways in which insects help humans, and the crucial role they play in pollination and maintaining a balance in the ecosystem. My Book of Bugs is a wonderful introduction to insects and their many incredible feature

Inside Scouts: An Acorn Book (Book1-3)The Inside Scouts Viv and Sanjay help a lion with a leaky heart in this full-color early reader series!Pick a book. Grow a Reader!This series is part of Scholastic's early reader line, Acorn, aimed at children who are learning to read. With easy-to-read text, a short-story format, plenty of humor, and full-color artwork on every page, these books will boost reading confidence and fluency. Acorn books plant a love of reading and help readers grow!Viv and Sanjay are the Inside Scouts! Together, they help animals. They have a cool superpower -- they can shrink super small. When a lion with a leaky heart needs help, the Inside Scouts know what to do! They put on their suits, grab their tools, and get really small. They go inside the lion to find the leaky spot. And they fix it together!This series introduces beginning readers to the human body through mammals with similar anatomy -- and it does so in really fun ways! In this first book, readers learn a

Oscar the Grouch meets Frog & Toad in this hilarious illustrated early reader series about a cranky wolf on a quest to be left alone. Wolf has just the right amount of friends: NONE. He loves to be alone. Unfortunately, everywhere he goes, other people are there too. At school, the teacher says if he can't get along with the other students, he has to leave. So he goes to the movies. More people! He tries the beach. No peace there, either. He flees to the remote peak of a mountain, and even there, someone comes along to bother him. Finally, Wolf hatches a plan. All these people arrive for a party at Wolf's house . . . while Wolf makes a quick exit. Move over, Elephant & Piggie! For readers who have had enough of the buddy duos, for kids who'd rather play by themselves--Wolf is the antihero you've been waiting for. Lone Wolf Goes to School is the first in a hilarious early reader series starring the completely lovable, chronically grumpy Wolf, a character who affirms kids who fly

The Prince and the Dressmaker author Jen Wang spins a sensitive narrative about an alienated teen who leaves modern society for the California wilderness to start a new life away from human kind.Ash has always felt alone. Adults ignore the climate crisis. Other kids Ash’s age are more interested in popularity contests than in fighting for change. The only person who seemed to understand how desperate things were was Ash's grandpa, Edwin.Before he died, Edwin used to talk about building a secret cabin, off the grid in the California wilderness. And to Ash, that maybe-mythical cabin is starting to feel like the perfect place for a fresh start and an escape from the miserable feeling of alienation that haunts their daily life.But making the wilds your home isn’t easy. And as much as Ash wants to be alone . . . can they really be happy alone? Can they survive alone?From New York Times–bestselling author and illustrator Jen Wang comes a singularly affectingstory about self-discovery, self-r

Ursula finds confidence in seeing the world her own way in another innovative, flipped-format picture book from Caldecott Honoree and Geisel Award winner Corey R. Tabor.Ursula is a happy catfish, swimming through a shimmering river with weeds waving above and a sky full of scrumptious bugs below.Then one question turns her world upside down.Is left right? Is right wrong? Which way even is up?From the Caldecott Honor–winning creator of Mel Fell comes another innovative, flipped-format picture book that encourages children to find confidence in their individuality.

"Max in the House of Spies is everything you could hope for in a book," -R. J. Palacio, #1 New York Times bestselling author of Wonder, White Bird, and Pony "Espionage! Secrets! Suspense! If you've ever dreamed of being a spy, this book is for you." -Alan Gratz, #1 New York Times bestselling author of Refugee and Projekt 1065 Max Bretzfeld doesn't want to move to London. Leaving home is hard and Max is alone for the first time in his life. But not for long. Max is surprised to discover that he's been joined by two unexpected traveling companions, one on each shoulder, a kobold and a dybbuk named Berg and Stein. Germany is becoming more and more dangerous for Jewish families, but Max is determined to find a way back home, and back to his parents. He has a plan to return to Berlin. It merely involves accomplishing the impossible: becoming a British spy. Thought-provoking historical fiction with a dash of magic, Max in the House of Spies is a World War II story as only acclaimed storytell

Mo Willems, #1 New York Times bestselling, award-winning author-illustrator, tackles a BIG concept in this hilarious nonfiction picture book about the relationship between size and scale. Are YOU big? A simple question sends readers to the far reaches of the universe. From an average-size kid . . . to a hot air balloon . . . to a storm cloud . . . to the M100 Galaxy, size is a matter of perspective. Bold text, expressive art, and real-world science come together in this original Mo Willems STEAM-based, early-learning concept book.

Fairies, dragons, wizards, and more await Geronimo on every magical Kingdom of Fantasy adventure!Geronimo's sixteenth adventure in the Kingdom of Fantasy!I, Geronimo Stilton, have been called to the Kingdom of Fantasy so many times. Each visit is more of an adventure than the last!This time there was big trouble! Queen Imaginaria has been kidnapped. The evil witch is using her wand to take treasures from the kingdom. Can I help stop the evil witch before all the treasures are gone?

CEFR Correlation:A2Get Ready for International BusinessTo be ready to use English in the workplace, students need to• be exposed to a variety of business and workplace situations• build confidence in using English communicatively for workGet Ready for International Business helps students prepare to use English in the workplace by• exposing them to English being used in a range of different business contexts• giving students practice in reading an assortment of texts• offering a variety of different accents in the listening exercises and the cross-cultural Viewpoints sections that feature a wide range of people talking about aspects of business and culture• focusing on developing learners’ listening and speaking skills through carefully graded activities• explicitly teaching key conversation strategies to help them manage conversations in business settings• providing In business tasks that allow students to use the language studied in business simulations to develop their own professio

本書特色 這是一本因應電腦世代 (computer age) 所寫成的統計學教科書。書中增加了有關 R 語言的介紹,並盡可能在各個章節中,說明電腦以及 R 語言如何在機率與統計推論上,發揮其功用。其中,我們在第 19 章介紹蒙地卡羅模擬與 Bootstrap 樣本重抽法,希望讀者對於如何以電腦運算能力輔助統計推論能有一較為深入的認識。本書的章節安排,是根據我在台大經濟系講授 「統計學」 課程的多年教學經驗所整理出之架構。在介紹完機率模型後,緊接著介紹單變量與多變量隨機變數。關於動差的討論,則是從隨機變數的章節抽離出來,獨立成為第 5 章。同時,亦將常態分配以及與其相關的重要分配如卡方分配,學生 t 分配與 F 分配等,以一獨立章節 (第 6 章) 介紹。這本書的設計目標是,讓學生在得到足以駕馭統計推論的機率理論 (隨機變數,動差,常態分配,抽樣分配與大樣本理論) 之後,就開始一窺統計推論之堂奧。至於其他常用的離散與連續隨機變數,則移到統計推論相關章節的後面,因此,如果是一學期的統計課程,只要專注在第 1 到 11 章即可,關於其他常用離散與連續隨機變數之介紹,可於學期末得空時再補充。我在本書中不再討論變異數分析 (ANOVA),有興趣的讀者請自行參考陳旭昇 (2015)。

Understanding money today is so much more than learning about notes and coins. Where does money come from? Why do I have to save? What happens if I click BUY NOW? Find answers to important money questions, and some silly ones too in this friendly and useful book.- The question and answer lift-the-flat format is a perfect reading tool for curious kids- Written in consultation with money management expert Bobby Seagull - TV and radio presenter, teacher and ambassador for the National Numeracy charity- Early learning about money is key to building good money habits

From the Amazon rainforest in South America to the Congo in Central Africa, find the animals hidden in each scene using the special "flashlight" included in the book. Who's hiding in the grass? And what about the shadow in the branches of that tree? Thanks to the magic flashlight in this book, children will be entertained looking for more than 60 animals hidden in the wonderfully illustrated pages. Each spread highlights a different part of the world and provides bite-sized facts about the creatures found in that jungle.

本書為進階的教材，需要經濟計量方法和矩陣代數的基礎。時間序列預測是統計學裡非常實用的工具，不論是分析投資組合的數據、全球總經和金融市場，以及預測景氣循環變動等等，可以用過去的數據資料，預測未來趨勢，是可以符合實際決策需要的實用能力。書中並介紹機器學習方法，機器學習不是指特定估計方法，學習指的是如何在資料結構中運算，以追蹤最小預測誤差的方法獲得最佳預測(tuning)。我們應用機器學習演算法訓練歷史資料，執行特徵萃取(features extraction)，再測試預測表現。依此建立一個可預測未來的模型，作為決策之用。使用R語言進行時間序列預測是本書的一大特點，R語言是統計學中普及且容易上手的分析工具，書中針對一個個資料分析步驟進行深度解說，教給讀者進行預測與評估的最實用方法。

Boom! Crash! Crumble! A wrecking ball smashes into the side of a building, sending pieces flying. It’s an awe-inspiring sight. It’s also science!This book explores how things break down, crack, explode, crumple, and shatter. This fun, unique take on a how-things-work book explores the world through the lens of what it takes for things to, well, not work. In these vibrantly illustrated pages, you’ll peer through the smoke and rubble of controlled demolitions to discover the properties of building materials. Then get a glimpse of the inner workings of a cracked cell phone screen, peek carefully at mega-avalanches and sinkholes, and hold on tight as wrecking balls swing and car crushers crunch metal. Buckle up with crash-test dummies and travel back in time to explore the world’s most famous failures (looking at you, Leaning Tower of Pisa).Featuring hands-on activities that walk kids through their own experiments in destruction, Break Down! will change the way you look at the world.Topics

It’s eat or be eaten...literally!Locked in battle with the Lunatic Magician, Laios is the last man standing against an array of the dungeon’s deadliest dragons. Using his extensive monster knowledge to his advantage, Laios manages to defy the odds of almost certain death―at least until Sissel devises an even more terrible plan! Will Laios’s love of dungeon dining prove to be his downfall?

繼《Lion Needs a Haircut》知名童書作家Hyewon Yum再次帶來溫馨的兒童生活教養繪本。看醫生一點都不可怕，讓勇敢的獅子哥哥為第一次看診的妹妹當個好模範吧！A lion family navigates their fears of going to the doctor in this adorable, hilariously relatable companion to Lion Needs a HaircutLittle lion Luka is NOT worried about a visit to the doctor. He’s NOT scared of getting a shot. And he’s definitely NOT a little lion anymore. R-O-A-R!His younger sister, Lulu, might be nervous for her first checkup―but no need to worry, big brother is here to set a brave example. Step by step, he walks her through what will happen, offering encouragement and holding her hand. But when it’s his turn, on second thought, maybe he doesn’t need to see Dr. Brown today; he’s feeling perfectly fine, after all.This witty, tender story follows two siblings sharing a universal experience together, giving each other courage and realizing that a trip to the doctor’s office isn’t so bad.

A Magic Spark: An Acorn Book (Fairylight Friends #1)Time to Shine: An Acorn Book (Fairylight Friends #2)Full Moon Party: An Acorn Book (Fairylight Friends #3)Travel to a magical moonlit party with fairy friends Ruby, Iris, and Pip in this wondrous early reader series!Pick a Book. Grow a Reader!This series is part of Scholastic's early reader line, Acorn, aimed at children who are learning to read. With easy-to-read text, a short-story format, plenty of humor, and full-color artwork on every page, these books will boost reading confidence and fluency. Acorn books plant a love of reading and help readers grow!Best friends Ruby, Iris, and Pip are on their way to a full moon party! In five dazzling stories, the fairy friends use their powers to create their own ride, play fun games to win prizes, and have a dance party! With easy-to-read text and charming full-color artwork throughout, this series is perfect for beginning readers!

只能跑出統計報表的統計套裝軟體落伍了，讓統計專家以及程式高手帶著您，透過AI來幫您做統計計算、分析與解讀！R語言是進入統計學領域的一把重要鑰匙，本書從基礎開始，一個個步驟帶您領會運用R語言的樂趣。R 是一種專門為統計分析與資料管理所設計的手稿語言。R 誕生於90 年代初期，由S 語言所轉變而來。它是免付費的公開軟體，可自由下載原始碼，加上十分容易在官方網站找到別人寫好的套件或分析程式碼，因此近年來使用的人越來越多，並且不乏許多專業人士如：風險分析師、研究學者、統計學家等。本書會從入門的安裝步驟開始，介紹R的資料型態、資料整理、繪圖、推論統計的概念、變異數分析等，幫助讀者打好基礎，讀完您會發現，原來統計就是這麼輕鬆啊！

哈伯實業DATA MATE──創立於1985年，以DATA MATE行銷世界，並為歐洲、美國、日本等品牌ODM代工，以及國內各大機關公司企業提供完善多元之整體服務，為工商日誌、萬用手冊之領導品牌。DATA MATE本著專業技術、堅持嚴謹的品質保證，追求產品創新設計，不斷提升效率產能降低成本，使我們在二十一世紀繼續保持領先。品名：現代美學 6孔夾活頁萬用手冊 B6材質：PU變色皮包裝規格：H21xW

哈伯實業DATA MATE──創立於1985年，以DATA MATE行銷世界，並為歐洲、美國、日本等品牌ODM代工，以及國內各大機關公司企業提供完善多元之整體服務，為工商日誌、萬用手冊之領導品牌。DATA MATE本著專業技術、堅持嚴謹的品質保證，追求產品創新設計，不斷提升效率產能降低成本，使我們在二十一世紀繼續保持領先。品名：現代美學 6孔夾活頁萬用手冊 B6材質：PU變色皮包裝規格：H21xW

哈伯實業DATA MATE──創立於1985年，以DATA MATE行銷世界，並為歐洲、美國、日本等品牌ODM代工，以及國內各大機關公司企業提供完善多元之整體服務，為工商日誌、萬用手冊之領導品牌。DATA MATE本著專業技術、堅持嚴謹的品質保證，追求產品創新設計，不斷提升效率產能降低成本，使我們在二十一世紀繼續保持領先。品名：現代美學 6孔夾活頁萬用手冊 B6材質：PU變色皮包裝規格：H21xW

Moby Shinobi and Toby, Too! An Acorn Book (Book 1-3)Moby Shinobi and his sidekick Toby are heading to the beach in this action-packed, rhyming early reader!Pick a book. Grow a Reader!This series is part of Scholastic's early reader line, Acorn, aimed at children who are learning to read. With easy-to-read text, a short-story format, plenty of humor, and full-color artwork on every page, these books will boost reading confidence and fluency. Acorn books plant a love of reading and help readers grow!Moby Shinobi and his dog Toby are excited for a day at the beach! Moby tries to use his ninja skills to build a huge sand castle, catch some fish, and save a leaking sailboat... but each try ends in a mess! What if Moby isn't right for the job? But with some help from Toby, he discovers that teamwork makes every job easier! With easy-to-read rhyming text and full-color artwork throughout, this early reader series is sure to be a hit with beginning readers!

哈伯實業DATA MATE──創立於1985年，以DATA MATE行銷世界，並為歐洲、美國、日本等品牌ODM代工，以及國內各大機關公司企業提供完善多元之整體服務，為工商日誌、萬用手冊之領導品牌。DATA MATE本著專業技術、堅持嚴謹的品質保證，追求產品創新設計，不斷提升效率產能降低成本，使我們在二十一世紀繼續保持領先。品名：義式典雅 6孔夾活頁萬用手冊材質：PU變色皮商品規格：H21xW17.

哈伯實業DATA MATE──創立於1985年，以DATA MATE行銷世界，並為歐洲、美國、日本等品牌ODM代工，以及國內各大機關公司企業提供完善多元之整體服務，為工商日誌、萬用手冊之領導品牌。DATA MATE本著專業技術、堅持嚴謹的品質保證，追求產品創新設計，不斷提升效率產能降低成本，使我們在二十一世紀繼續保持領先。品名：義式典雅 6孔夾活頁萬用手冊材質：PU變色皮商品規格：H21xW17.

YA！我喜歡統計學！R語言版來了！你也許常聽到「統計學好難喔」、「念統計有什麼用」這樣的話，那只是很少人發現統計學的魅力，這本書將顛覆你的刻板印象！外表看似枯燥又艱深，骨子裡卻是有趣又實用，講解觀念親切生動，讓你一不小心就愛上統計學了。※每章均附「真實世界的統計」，讓你知道統計其實默默地貼近你的生活。※互動式學習網站加深你與統計學的情感連結。※本書附有資料檔，請至五南官網輸入本書書號，即可找到資料

NEW YORK TIMES BESTSELLERNow in paperback--Peggy Orenstein, author of the groundbreaking New York Times bestseller Girls & Sex, turns her focus to the sexual lives of young men. "Eye-opening.... Every few pages, the boy world cracks open a little bit.... Even in the most anxiety-provoking moments of Boys & Sex, it's clear that Orenstein believes in the goodness of boys and the men they can become, and she believes in us, as parents, to raise them" (New York Times Book Review).Peggy Orenstein's Girls & Sex broke ground, shattered taboos, and launched conversations about young women's right to pleasure and agency in sexual encounters. It also had an unexpected effect on its author: Orenstein realized that talking about girls is only half the conversation. Boys are subject to the same cultural forces as girls--steeped in the same distorted media images and binary stereotypes of female sexiness and toxic masculinity--which equally affect how they navigate sexual and emotional r

The true tale of Irena Sendlerowa, a social worker in the Warsaw ghetto in the early 1940s, during the early days of German occupation. She is credited for saving the lives of 2500 Jewish children by gradually and quietly smuggling them to safety in small groups. While she is eventually arrested by Gestapo, imprisoned, and tortured for her actions, she refuses to reveal her network and is condemned to death. She is ultimately saved from death by other members of her organization.This second volume focuses on Irena's activities following her incarceration, and her years long mission to locate and reunite the rescued children with their families, which led decades later to her ultimate recognition. Her attempts to locate each of their natural parents for reunion were as often heartbreaking as fulfilling. And while most of the parents had been gassed in the Holocaust, she made it her mission to help those orphaned find new homes.

In the late 19th and early 20th century, a combination of coastal defence for the homeland and fleet defence for the East Indies became the established naval strategy for the Royal Dutch Navy and set

A coming-of-age story about learning to celebrate yourself -- and teaching the world to recognize you, too -- perfect for fans of R. J. Palacio's Wonder!"This glimpse into the world of a young autisti

THE REESE WITHERSPOON X HELLO SUNSHINE BOOK CLUB PICK FOR NOVEMBER AND USA TODAY BESTSELLER"One of the most twisted and entertaining plots."—Reese Witherspoon"Whiplash-inducing."—New York Times Book R

Build early mathematics skills like counting, number recognition, understanding relative quantity and size, and more with Number Circus!. This large, sturdy lift-the-flap book teems with humorous vign

本書特色■ 以SPSS最新版本SPSS 23～25進行全面編修，更新介面說明，增補新增功能介紹，充分發揮SPSS優勢長項。■ 納入免費軟體R的操作介紹與實例分析，搭配統計原理與SPSS的操作對應，擴展學習視野與分析能力。■ 強化研究上的實務解決方案，充實變異數分析與多元迴歸範例，納入PROCESS模組，擴充調節與中介效果實作技術，符合博碩士生與研究人員需求。量化研究是當代社會與行為科學的強勢典範，

The instant New York Times bestseller, "A must-read for anyone who thinks 'build a wall' is the answer to anything." --EsquireFor Francisco Cantú, the border is in the blood: his mother, a park ranger and daughter of a Mexican immigrant, raised him in the scrublands of the Southwest. Haunted by the landscape of his youth, Cantú joins the Border Patrol. He and his partners are posted to remote regions crisscrossed by drug routes and smuggling corridors, where they learn to track other humans under blistering sun and through frigid nights. They haul in the dead and deliver to detention those they find alive. Cantú tries not to think where the stories go from there.Plagued by nightmares, he abandons the Patrol for civilian life. But when an immigrant friend travels to Mexico to visit his dying mother and does not return, Cantú discovers that the border has migrated with him, and now he must know the whole story. Searing and unforgettable, The Line Becomes a River goes behind the headlines