Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

A unique treasury of words especially written for children in grades K-2, ages 5-7.This beginner's dictionary introduces young readers to 3,000 words using 1,000 entries and hundreds of captivating illustrations by beloved children's illustrator, Ruth Heller. With this indispensable learning tool, children will have fun discovering more about words, their meanings, and how to spell them.*Teaches basic dictionary skills: alphabetization, spelling, parts of speech, letter sounds, use of synonyms and antonyms, and homographs and homophones*Jokes, riddles, poems, and fun facts all about words make learning fun*References to popular stories, fairy tales, myths, and nursery rhymes spark imagination and encourage language exploration*Words, phrases, and their meanings are discussed in full age-appropriate sentences, with usage examples to show how they are used in context Discover a world of information in this engaging, full-color dictionary for children!專為 K-2 年級、5-7 歲兒童編寫的獨特詞彙寶庫。這本初學者字典透過深

2022年藍彼得圖書獎入圍書！以趣味生動的漫畫形式，圖解石器時代史前人類的食衣住行與生存智慧 。翻開本書，加入你的穴居朋友，一同打獵、製作生活工具，展開石器時代精彩刺激的一天吧！Shortlisted for the Blue Peter Awards 2022 Best Books with FactsSet in Northern Europe around 18,000 years ago, this fascinating information book explores a day in the life of a typical Stone-Age child. Auri lives with her extended family in a cave, which shelters them from bad weather, provides protection from dangerous animals and is close to the river, where they gather fresh water and food.Readers will learn key skills alongside Auri, as her dad shows her how to make and set a fish trap, while Grandpa demonstrates how to fashion a sharp spear from sticks and flint. She explains how to track animals by looking for footprints, nibbled plants and droppings, and make fire using a few simple handmade tools.This fictional account of a Stone-Age family enables young readers to imagine what life may have been like for a child of their age. The comic strip illustrations are colourful, humorous and infor

莫內喜歡畫光，特別是清晨河面的光。他不跟從傳統的畫法，而是用自己的方式，捕捉眼前轉變的景色。一開始沒有人懂他的畫，但他不氣餒，持續創作，最後讓大家看見畫裡的光和感覺。這本繪本帶我們認識這位愛畫光的畫家，也鼓勵我們用自己的眼睛看世界。A new picture book about the iconic artist Claude Monet, from the Caldecott-Award winning team that created The Noisy Paint Box.Claude Monet is one of the world's most beloved artists--and he became famous during his own lifetime. He rejected a traditional life laid out clean and smooth before him. Instead he chose a life of art. But not just any art: a new way of seeing that came to be called impressionism.Monet loved to paint what he saw around him, particularly the Seine River. He was initially rejected for using bright colors, tangled brushstrokes--condemned for his impressions. But soon art dealers and collectors were lining up each morning to see as Monet saw. Monet, however, waited only for the light. The changing light...each morning he had a dozen canvases on hand to paint a dozen different moments. His brush moved back and forth, chasing sunlight--putting in the

Join a little boy searching the farm for his breakfast one fine morning in this charming picture book from bestselling author Mem Fox and award-winning illustrator Christine Davenier.Early one morning

From New York Times bestselling author Mac Barnett and Geisel Award-winning illustrator Greg Pizzoli, an uproarious early reader series about a mischievous rabbit, a cranky old lady, and a lovable dog

作者艾瑪‧達德 Emma Dodd曾於2010 以 I Love My Mummy獲得英國圖書信託基金會幼兒讀物獎（Booktrust Early Years Awards）；2011年以I Love Bugs入圍凱特‧格林威獎英國暢銷得獎童書作家：艾瑪‧達德作品\ 甜到心坎裡的親子繪本 /我很小……這個世界好大，而我這麼小；這個世界這麼快，而我這麼小；風如此強勁、冬天如此悠長，而我這麼小；世間萬

Crack the case with Sherlock Holmes in three familiar tales, now written with young readers in mind: “The Red-Headed League,” “The Speckled Band,” and “The Hound of the Baskervilles.”It’s always an adventure with the world’s smartest detective and his trusty partner, Dr. John Watson! With mysteries galore, the daring duo can solve anything when they put their minds to it.Follow Sherlock and Watson as they track down clues and uncover the answers to strange events: a tricky business scheme; a crime in a locked room; and the appearance of an eerie, supernatural legend. Wherever the two go, the truth is sure to follow.With foil on the cover and evocative full-color art from Carlo Molinari, this adaptation of Sir Arthur Conan Doyle’s iconicSherlock Holmespromises to be an exciting first chapter book.From Starry Forest Books,Classic Adventuresbrings action-packed adaptations of favorite classics to early readers.

City Hall is the first book to feature striking contemporary images of the most architecturally significant city halls in the United States. This diverse collection includes New York, the oldest; Philadelphia, once the tallest building in the world; and Boston, the first major brutalist building in the United States. Organized chronologically, the book traces the evolution of American civic architecture from the early 19th century to the present day and represents diverse styles such as Federalist, art deco, and modern.Architects, current and former mayors, historians, and preservationists tell the story of how each city hall came to be, what it says about its city, and why it's important architecturally. With a foreword by noted historian Douglas Brinkley and an essay by architectural writer Thomas Mellins, City Hall spotlights these often underappreciated civic buildings and affirms architecture's unique power to express democratic ideals and inspire civic engagement.

From New York Times bestselling author Mac Barnett and Geisel Award-winning illustrator Greg Pizzoli, an uproarious early reader series about a mischievous rabbit, a cranky old lady, and a lovable dog

Charise Mericle Harper (Crafty Cat, Just Grace, Fashion Kitty) delivers another hilarious and charming early graphic novel series starring Pepper and Boo, two darling dogs, and their suspicious housem

From award-winning, best-selling author and illustrator Mo Willems comes a bind-up of five Elephant & Piggie adventures to help foster early readers' problem-solving skills. Titles include: There

The B on Your Thumb is a book of rhymes and delightful ditties to boost early reading. Each rhyme teaches a particular sound, spelling, or rule, and will delight young children with the silliness of t

本書介紹 Marie Tharp──第一位描繪出地球海底中央海嶺全貌的女性科學家。自小喜歡觀察世界、熱愛解謎的她，不願受限於時代對女性的期待。二十世紀中期，女性在科學領域並不受歡迎，海上研究更被視為「不適合女性」。Marie 因此無法登船，只能留在實驗室處理同事帶回的資料。然而，她並未因此退縮，而是逐點分析、逐張描繪，慢慢看見海底深處一條巨大裂谷的形狀。儘管科學界一開始對她的發現存疑，但她的資料與推論無懈可擊，最終證實自己觀察正確。這條海底山脈——世界上最大的地理構造——就從她狹小的辦公桌上被完整繪出。溫和呈現女性科學家的堅持與勇氣以易懂方式介紹海底地形與研究歷程適合作為科學啟蒙與女性人物傳記Meet Marie Tharp (1920-2006), the first person to map the Earth’s underwater mountain ridge, in this inspiring picture book biography from the author of Shark Lady.From a young age, Marie Tharp loved watching the world. She loved solving problems. And she loved pushing the limits of what girls and women were expected to do and be. In the mid-twentieth century, women were not welcome in the sciences, but Marie was tenacious. She got a job in a laboratory at Cambridge University, New York. But then she faced another barrior: women were not allowed on the research ships (they were considered bad luck on boats). So instead, Marie stayed back and dove deep into the data her colleagues recorded. S

From New York Times bestselling author Mac Barnett and Geisel Award-winning illustrator Greg Pizzoli, an uproarious early reader series about a mischievous rabbit, a cranky old lady, and a lovable dog

From New York Times bestselling author Mac Barnett and Geisel Award-winning illustrator Greg Pizzoli, an uproarious early reader series about a mischievous rabbit, a cranky old lady, and a lovable dog

Over almost a century, the NFL has provided fans with hundreds of unique personalities, countless unforgettable moments and some of the greatest feats of sporting brilliance ever seen. From its humble beginnings in the Midwest to the global phenomenon it has become today, the league has evolved and changed almost beyond recognition. But the exploits of the footballing heroes of years past continue to stand the test of time. Here we've collected stories on dozens of the league's most celebrated players. With Future Publishing's extraordinary content, expert commentary and lavish photography, you'll explore and rediscover the attributes that made these players, coaches and teams iconic, as well as the moments that propelled them to greatness. From early innovators like Don Hutson and Jim Brown, to modern giants such as Tom Brady, there's something for every NFL fan here.

Plants-Only Kitchen offers an explosion of flavour, with more than 70 vegan recipes that work around your lifestyle. With symbols flagging whether recipes are high-protein, take less than 15 minutes, or are suitable for meal prep and batch cooking, Plants-Only Kitchen explains how best to make a vegan diet work for you. No fuss, no fancy ingredients - just fantastic food using plants, only. Gaz Oakley (aka @avantgardevegan) has amassed well over a million followers on social media with his exciting vegan dishes, which emphasize that a plant-based diet doesn't mean missing out on taste. In Plants-Only Kitchen, Gaz's recipes are easier than ever before - following his step-by-step instructions, tips and advice, anyone can cook great vegan food.

Take to the trails for a celebration of nature — and a day spent with dad.In the cool and quiet early light of morning, a father and child wake up. Today they’re going on a hike. Follow the duo into t

It's early spring and below the earth's surface seeds are just starting to sprout. One by one they stretch through the dirt and towards the sun, extending their shoots and leaves and growing tall. All

"This is a perfect book for a dinosaur storytime."—School Library JournalWinner 2021 CLEL Bell Award for SINGfrom Colorado Libraries for Early LiteracyThis STEM-friendly musical fossil dig will have dinosaur lovers singing along as they learn the science behindpaleontology.Set to the tune of "Here We Go 'Round the Mulberry Bush,"Here We Go Digging for Dinosaur Bonesinvites budding paleontologists and dinosaur fans on an exciting fossil dig. Readers will hike the trail, scan the ground, and make a find—then discover how to build a T. Rex from its bones.

From New York Times bestselling author Mac Barnett and Geisel Award-winning illustrator Greg Pizzoli, an uproarious early reader series about a mischievous rabbit, a cranky old lady, and a lovable dog

介紹影片 https://youtu.be/_pm3LdmszRA https://youtu.be/uHMjS4kvVlA 內容簡介 最多MOF、世界甜點冠軍參與 收錄全世界頂尖糕點師的原創作品！ 網羅所有糕點製作必備的技巧、建議、與訣竅！ 從食材的選擇˙搭配˙組成˙應用，傳授詳盡知識與變化 集結MOF法國最佳職人，與世界甜點冠軍！ 能夠在一本書中，集結最多的MOF和世界甜點冠軍，全世界只有「R

From Edouard Manet’s portrait of naturalist writer Émile Zola sitting among his Japanese art finds to Van Gogh’s meticulous copies of the Hiroshige prints he devotedly collected, 19th-century pioneers of European modernism made no secret of their love of Japanese art. In all its sensuality, freedom, and effervescence, the woodblock print is single-handedly credited with the wave of japonaiserie that first enthralled France and, later, all of Europe—but often remains misunderstood as an “exotic” artifact that helped inspire Western creativity. The fact is that the Japanese woodblock print is a phenomenon of which there exists no Western equivalent.Some of the most disruptive ideas in modern art—including, as Karl Marx put it, that “all that is solid melts into air”—were invented in Japan in the 1700s and expressed like never before in the designs of such masters as Hokusai, Utamaro, and Hiroshige in the early 19th century. This book lifts the veil on a much-loved but little-understood a

To know where we are going, we must also know where we came from. This book gives an account of Hong Kong’s medical and health development from the Second World War to the present day, investigat

Catalog Copy:From award-winning, best-selling author and illustrator Mo Willems comes a bind-up of five Elephant & Piggie adventures to spark early-readers' imaginations. Titles include:1. I

From New York Times bestselling author Mac Barnett and Geisel Award-winning illustrator Greg Pizzoli, an uproarious early reader series about a mischievous rabbit, a cranky old lady, and a lovable dog

From New York Times bestselling author Mac Barnett and Geisel Award-winning illustrator Greg Pizzoli, an uproarious early reader series about a mischievous rabbit, a cranky old lady, and a lovable dog

The definitive, fully illustrated official companion to Stranger Things, detailing every aspect of the show’s development from page to screen. PLEASE NOTE: The distressed look of the cover is intentio

Submarines played a major role in the war at sea in the years 1939-45, and this major reference book describes all the classes of vessel that were deployed by the eighteen combatant nations during tho

BabyLit® Storybooks give classics new life for the next generation of early readers.In Anne of Green Gables, preschoolers get to know the beloved redheaded orphan Anne Shirley, who is sent to live wit

BabyLit® Storybooks give classics new life for the next generation of early readers.In The Jungle Book, preschoolers can tag along on Mowgli’s thrilling adventure, meeting wolves, elephants, and even

Gain a deeper understanding of oral health with the definitive text in oral histology. Written by Dr. Antonio Nanci, a world-renowned leader in cell biology, the new ninth edition of Ten Cate's Oral H

BabyLit® Storybooks give classics new life for the next generation of early readers. Ahoy! Come sail the ocean blue with Captain Ahab, Ishmael, Queequeg, and the rest of the crew! The search is on for

本書為電化學阻抗分析領域的重要經典，第二版在原有架構上全面擴充與修訂，系統性介紹阻抗光譜的理論基礎、實驗設計與資料詮釋方法。內容從複數運算、微分方程、電路模型談起，逐步延伸至動力學、質量傳輸、材料阻抗與頻率分散等核心議題，並加入更多範例與習題，協助讀者建立可實際操作的分析能力。作者特別強調如何從量測結果中萃取具物理意義的資訊，使本書不僅是理論教材，也是一部實務導向的研究指南，適合研究所課程與自學使用。The book is intended for use both as a professional reference and as a textbook suitable for training new scientists and engineers with emphasis placed on the applicable fundamentals rather than on detailed treatment of applications. It is intended to provide a background and training suitable for application of impedance spectroscopy to a broad range of applications such as corrosion, biomedical devices, semiconductors and solid-state devices, sensors, batteries, fuel cells, electrochemical capacitors, dielectric measurements, coatings, electrochromic materials, analytical chemistry, and imaging. The material is presented in a manner that facilitates sequential development of understanding and expertise either in a course or in self-study. Illustrative examples are interspersed througho

Presenting a global and interdisciplinary approach to plant ecology, this much-awaited new edition of the book Plants and Vegetation integrates classical themes with the latest ideas, models, and data. Keddy draws on extensive teaching experience to bring the field to life, guiding students through essential concepts with numerous real-world examples and full-colour illustrations throughout. The chapters begin by presenting the wider picture of the origin of plants and their impact on the Earth, before exploring the search for global patterns in plants and vegetation. Chapters on resources, stress, competition, herbivory, and mutualism explore causation, and a concluding chapter on conservation addresses the concern that one-third of all plant species are at risk of extinction. The scope of this edition is broadened further by a new chapter on population ecology, along with extensive examples including South African deserts, the Guyana Highlands of South America, Himalayan forests and

The idea of a right to privacy, which arose in reaction to the rapid rise of newspapers, instant photography and the “paparazzi” of the 19th century, has evolved into a constitutional right in much of

Minecraft 不只是遊戲，更是一個能動手思考的學習空間。本書從玩家熟悉的遊戲場景出發，介紹 redstone 方塊如何模擬現實世界中的電路與程式邏輯，讓讀者在建造機關與裝置的過程中，逐步理解編碼思維。內容著重於「怎麼想」而非死背指令，鼓勵讀者觀察、嘗試與修正。書中大量運用照片、示意圖與整理圖表，將抽象的程式概念轉化為可視化的操作流程，適合對科技、工程與創作有興趣的孩子閱讀。Introduced in 29, Minecraft™ has become an enormous success with gaming kids and adults. Users love exploring and building within Minecraft’s mind-bogglingly large environments. This game allows users to practice STEM skills while having fun. One of its greatest strengths is its ability to teach coding principles with “redstone” blocks. These blocks can be used to make exciting machines and devices in Minecraft’s virtual world. With this volume, readers will learn the logic and technology behind coding with Minecraft™. Photographs, diagrams, sidebars, and a graphic organizer help reinforce basic coding concepts.Minecraft is a trademark of Mojang (a game development studio owned by Microsoft Technology Corporation), and its use in this book does not imply a recommendation or endorsement of this titl

"The author provides unprecedented critical, interdisciplinary explorations of the complex dynamics and intersectionalities operating between disability and poverty in rural areas, an assumed relationship that is too often misunderstood. Reporting on long term ethnographic work in Guatemala and prioritising the voices, knowledge and narratives of disabled people and their families, Grech offers an incisive and refined critical analysis of the various complex barriers and interactions in the disability/poverty/rurality nexus encountered by what Grech calls 'disabled families'. The book opens up discussions on a broad range of themes traversing conceptual, spatial, historical, embodied, spiritual, racial, sexual and gendered terrains among others. It challenges and reframes established, often imposed discourses and practices, and contests issues of (re)presentation, Eurocentrism, and coloniality. Finally, it contributes new and uncharted reflections for further debate, which are indispen

An entertaining diary format based on this much-loved fairy tale, told from the perspective of the Ugly Duckling himself. Pop-ups bring the book to life, perfect for engaging early readers. Multi-medi

Here’s a beautiful historical fiction picture book—perfect for the Common Core—that provides a rare glimpse into the early childhood of Albert Einstein, the world’s most famous physicist. Three-year-o