Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

In this delightful book, a small boy imagines a world where dinosaurs perform public services. “Bold lines accentuate imaginative, humorous ideas. A natural for student response: students formulate their own outcomes about what would happen if the dinosaurs returned. An overwhelming favorite in the early grades.”--The Reading Teacher

Step out of your element with Science Comics: The Periodic Table of Elements, the latest volume of First Second's middle-grade nonfiction series!A book of fun chemistry experiments has fallen into the wrong hands. Only Mel can use her knowledge of the periodic table to put an end to a maniacal madman's evil schemes.The periodic table helps us quickly understand the 118 elements, those tiny substances that make up everything in the world. By using the periodic table, we can recognize how these building blocks behave, find trends and patterns in the universe, and make predictions about elements that haven’t been discovered yet. Join us in learning about the periodic table, and maybe the next big discovery will be yours!

Introduce your kindergartner to 60 new words and support early reading with fun stories, games, and word activities such as Bingo, drawing, word mazes, and more! A picture dictionary, mini books, and removable word cards provide additional learning fun.The whole language learning activities develop vocabulary, word recognition and writing skills, and support your child in early reading skills. Engaging stories with an audio read-aloud option help children learn new words independently and support language learners.My First Big Book of Words workbook for kindergarten includes: An audio read-aloud option that reads the directions and stories to your child, modeling correct intonation, expression, and pronunciationFun stories, activities, and games to help children learn new wordsTracing and writing activities that reinforce spelling and fine motor skillsPlus, removable word cards, mini books, a picture dictionary, and stickersSample words are in theme-based units and include: My Family:

Preschoolers are introduced to core science concepts with this playful format featuring 20 hands-on activities that use everyday household materials, including a vinegar volcano, a hula hoop count, and a kitchen sink or swim experiment. In this fourth book in the Busy Little Hands series, preschoolers get ready for a science adventure! Preschoolers wonder and explore with 20 hands-on experiments using everyday household objects and making daily activities such as snack time and play time into learning opportunities. Each play activity demonstrates a simple principle of physics, earth science, chemistry, or biology, including the Kitchen Sink or Float (demonstrating density), the Vinegar Volcano (pressure) and Blooming Colors (chromatography). Featuring bright, easy-to-follow photos specially designed for pre-readers, this book is packed with learning fun, plus it sets the groundwork for science success in kindergarten and beyond.

The brand new, read-in-one-sitting mystery from the bestselling author of THE GOLDFISH BOY. When a little white lie leads to a huge dose of trouble... Cole is the odd one out at school: the other kids

Welcome to the LEGO (R) Dreamzzz (TM) universe! Build your Mateo minifigure before joining him on an epic adventure to protect the dream world from the evil Nightmare King.

It’s fun to be smart! Packed with questions that promote language development, cognitive growth, and social skills, these illustration-based card decks are the key to making kindergarten fun.Loved by kids, teacher approved, and trusted by parents, Brain Quest Kindergarten question-and-answer cards help children explore and learn about phonics, word study, counting, opposites, early adding and subtracting, and more! In a set of two decks, Brain Quest Kindergarten features hundreds of questions to help kids learn exactly what they need to know, when they need to know it.

Steve Spangler’s Super-Cool Science Experiments for Kids is a collection of 50 startling projects that encourage kids to question the world around them and how it works.This book presents the most ama

Down where worms wriggle and microbes squirm, there's a whole world waiting to be discovered...Under Your Feet delves beneath the Earth's surface and explores the diverse wonders hidden there. Encounter creatures of the deep and marvel at the mind-boggling size of the humongous fungus - the biggest organism in the world. Learn how one handful of ordinary soil contains more organisms than there are people on Earth, and carry out experiments using dirt from your own back garden.Under Your Feet offers you the opportunity to expand your knowledge of the natural world and soil-dwelling creatures big and small. Bursting with colorful illustrations and photography, this is the perfect book for budding young plant experts, animal fanatics, and geologists, and anyone who is curious about the ground we walk on.

Aasif Mandvi—best known for his work as a correspondent on The Daily Show with Jon Stewart—has been dealing with identity issues across three continents and 30 years. With wit, smarts, and a good dose

Get ready to lift the flaps, giggle, and discover a rainbow of fun! In this interactive call-and-response book, young children are invited to lift the flaps to reveal the answers about the colors of some of their favorite things. From pink chocolate cake to green clouds, and even zebras with polka dots, the silly suggestions will have kids laughing out loud while learning all about colors.• A visual play-and-learn adventure that stimulates early learning and encourages creativity• An irresistible introduction to the basic concept of colors• Sturdy board book design with 16 big flaps that's just right for little handsWith its big flaps, Lift and Play: Colors is a lively introduction to the world of colors that children will turn to again and again!• Great family read-aloud book• Books for 3–5 years old• Books for preschool and kindergarten children

Early Readers are stepping stones from picture books to reading books. A blue Early Reader is perfect for sharing and reading together. A red Early Reader is the next step on your reading journey.Horr

The unimaginable has happened - Longevity, the drug that is supposed to guarantee eternal youth, isn't working. A virus is sweeping the country, killing many in its wake, and Longevity is powerless t

DK's award winning Eyewitness Video series, now on DVD! Life goes back billions of years to the bubbling cauldron of the early Earth and life's primitive beginnings, chronicling the development of org

Describes why things float or sink and presents simple experiments to demonstrate the scientific principles involved.

'A superb chronicler of cop culture' -SUNDAY TIMES'Disher is the gold standard for rural noir' - CHRIS HAMMER'The equal of Joseph Wambaugh and James Lee Burke' -THE TIMESONLY FIRE WILL REVEAL THE TRUTHIt's bushfire season and pressure is building for the Waterloo Police Department. Two bodies have been found in a burnt-out car, and Detective Inspector Hal Challis suspects that they are linked to the sudden increase in drug suppliers flooding the Mornington Peninsula.When Melbourne's Major Drug Division starts blocking his every move, Challis is certain of the connection. But with the team occupied by the hunt for a serial predator, an investigation into elusive hitmen and the discovery of an abandoned meth lab, it seems fires are the least of Waterloo's problems.From the multiple Ned Kelly Award-winning author ofConsolationandDay's Endcomes the final Hal Challis investigation, for readers of Jane Harper, Ian Rankin and Chris Hammer.

This hands-on (and marker-on!) curriculum-based workbook provides reinforcement, practice, and review opportunities of foundational pre-math and pre-reading concepts plus motor skill work for the youngest learners. The ultimate write and erase workbook, with tons of curriculum-based activities and exercises focusing on letters, numbers, colors, and shapes. Includes a removable double sided white board and dry erase marker (attached in spiral binding). It's fun to be smart! From the brand that's loved by kids, teacher approved, and parent trusted, Brain Quest Write and Erase: Preschool Skills is packed with hands-on activities that introduce and reinforce concepts students need to prepare for school. Bonus questions on each page extend the learning and give parents ample opportunities for engaging conversations and language development. Aligned with early learning standards and expertly vetted by award-winning teachers, each page is designed to set students and parents

Trace the trails for search and find finger fun!Discover finger-tracing fun as you trace the trails and follow the shark through the busy under-the-sea pictures. There are peekaboo windows to peep through, and lots of splashing, snapping and swimming sea creatures to spot, too!Bright illustrations feature lots of detail to spot and words to say out loud, andaid development of first wordsand early reading.Perfect forsensory funandinteractive play.Helps to develop bothmotor and literacy skills.

Trace the trails for search and find finger fun!Discover search-and-find finger-tracing fun as you trace the trails and follow the tractor through the busy farmyard pictures!Each scene is full of lots of neighing, oinking, and baaing farm animals to spot, too!Bright illustrations feature lots of detail to spot and words to say out loud, and aid development of first words and early reading.There are tactile trails to follow, bumpy textures to find and feel, plus peep-through windows lead you through the pages as you follow that tractor and find out where it is going!The tactile trails, bumpy textures and peep-through holes are perfect for sensory fun and interactive play.

Trace the trails for search and find finger fun!Discover search-and-find finger-tracing fun as you trace the trails and follow the truck through the busy pictures!Each scene is full of lots of beeping, chugging and rumbling vehicles to spot, too!Bright illustrations feature lots of detail to spot and words to say out loud, and aid development of first words and early reading.There are tactile trails to follow, bumpy textures to find and feel, plus peep-through windows lead you through the pages as you follow that truck and find out where it is going!The tactile trails, bumpy textures and peep-through holes are perfect for sensory fun and interactive play.

Fantasy meets crime caper in the first book of a landmark, enduringly popular epic series about a roguish group of conmen, which George R. R. Martin has called "fresh, original, and engrossing . . . gorgeously realized." An orphan's life is harsh--and often short--in the mysterious island city of Camorr. But young Locke Lamora dodges relentless danger, becoming a thief under the tutelage of a gifted con artist. As leader of the band of light-fingered brothers known as the Gentlemen Bastards, Locke is soon infamous, fooling even the underworld's most feared ruler. But in the shadows lurks someone still more ambitious and deadly. Faced with a bloody coup that threatens to destroy everyone and everything that holds meaning in his mercenary life, Locke vows to beat the enemy at his own brutal game--or die trying.

NEW YORK TIMES BESTSELLER - From world-renowned historian and philosopher Yuval Noah Harari, the bestselling author of Sapiens, comes an exciting, illustrated book for middle school readers that looks at the early history of humankind. A New York Times Best Book of the Year"Gripping and thought-provoking." --The New York TimesEven though we'll never outrun a hungry lion or outswim an angry shark, humans are pretty impressive--and we're the most dominant species on the planet. So how exactly did we become "unstoppable"? The answer to that is one of the strangest tales you'll ever hear. And it's a true story! From learning to make fire and using the stars as guides to cooking meals in microwaves and landing on the moon, prepare to uncover the secrets and superpowers of how we evolved from our first appearances on Earth millions of years ago. Acclaimed author Yuval Noah Harari has expertly crafted an extraordinary story of how humans learned to not only survive but also thrive on Earth, c

From BIG BANGS to tiny atoms SCIENCE tells us why things happen. Explore the whys, whats and hows of science and answer all the really BIG questions that curious kids are keen to ask. This playful rhyming book bubbles and bursts with all things scientific, from technology and space to experiments, inventions and the natural world.

It’s fun to be smart! These two illustration-based card decks are packed with early learning questions that promote language development, cognitive growth, and social skills for fifth graders.Loved by kids, teacher approved, and trusted by parents, Brain Quest For Threes question-and-answer cards help children explore and learn about the alphabet, counting, recognizing shapes, comparing and matching, and more! In a set of two decks, Brain Quest For Threes features hundreds of questions to help kids learn exactly what they need to know, when they need to know it.Featuring:Two full-color Q&A decks in a reusable flip-top storage boxA parent guide to help maximize the learning and fun300 questions that set the foundation for pre-school learningWhat’s New?Technology questions: Introduce children to the basics of computers and technologyExpanded social and emotional learning: Explores feelings and interactions with peersUpdated content: Fresh and relevant to today’s familiesBrain Quest d

It’s fun to be smart! These two illustration-based card decks are packed with early learning questions that promote language development, cognitive growth, and social skills for fifth graders.Loved by kids, teacher approved, and trusted by parents, Brain Quest For Twos question-and-answer cards help children explore and talk about daily routines, seasonal activities, and outings as they identify objects, shapes, colors, and more! In a set of two decks, Brain Quest For Twos features hundreds of questions to help kids learn exactly what they need to know, when they need to know it.Featuring:Two full-color Q&A decks in a reusable flip-top storage boxA parent guide to help maximize the learning and funOver 300 questions covering colors, counting, object identification, shapes, and moreWhat’s New?New content: Twenty-two brand-new cards added!Technology questions: Introduce children to the basics of computers and technologyExpanded social and emotional learning: Explores feelings and int

It’s fun to be smart! Packed with early learning questions that promote language development, cognitive growth, and social skills, these illustration-based card decks are the key to making Pre-K fun.Loved by kids, teacher approved, and trusted by parents, Brain Quest Pre-Kindergarten question-and-answer cards help children explore and learn about phonics, word study, counting, matching, sequencing, and more! In a set of two decks, Brain Quest Pre-Kindergarten features hundreds of questions to help kids learn exactly what they need to know, when they need to know it.Featuring:Two full-color Q&A decks in a reusable flip-top storage boxA parent guide to help maximize the learning and fun300 questions that set the foundation for learningWhat’s New?Technology questions: Introduce children to the basics of computers and technologyExpanded social and emotional learning: Explores feelings and interactions with peersUpdated content: Fresh and relevant to today’s familiesBrain Quest decks ar

Discover how space is part of our daily lives with Everyday STEM Science - Space, filled with facts, stories and experiments to try at home!Everyone knows there are planets and stars and space rocks, but how do these, and everything else in space, affect us on Earth? From the beginning of the universe and the origins of the planets, to the latest research and space missions, journey through space and uncover what is really out there . . .Discover how we're made of stars, find out how old you would be if you lived on Mars, and how time travel can happen in space. Plus, meet the explorers, astronomers and scientists whose discoveries have given us this fascinating space knowledge, including Mae Jemison, Stephen Hawking and Cecilia Payne-Gaposchkin. Readers can also carry out cool astronomical experiments at home.With easy-to-understand text written by science communicator and podcaster Izzie Clarke, and lots of colourful artworks, photos and diagrams, readers can best explore where we en

Brain Quest, America's #1 educational brand with more than 57 million copies in print, is now for babies! My First Brain Quest board books introduce essential early learning concepts and foundational vocabulary using engaging visuals and Brain Quest's signature question and answer format.From the rain in the sky to the grass at their feet, help your child understand the world around them with the guidance of this fun and exciting introduction to science!My First Brain Quest: First Words: Science Around Us introduces babies and toddlers to more than 100 STEM-related vocabulary words in their world—in the backyard, at the doctor's office, at the beach. Each scene features labeled illustrated objects as well as brief captions that help to introduce STEM concepts and help put into context, alongside questions that encourage conversation between reader and child. Children have fun naming, counting, and comparing.

Take a large group of kids in puberty, send them to a new school, and add a generous dose of tests, homework, and hormones, not to mention diverse personalities, bland food, and unpleasant odors. That’s middle school, and it can be a little . . . weird.Yes, there are cool things about middle school, like more independence, new friends, and new activities. But there’s baffling stuff too, like harsh judgment, the whole “popularity” thing, and, of course, drama. With insights from hundreds of students, this guidebook explores the halls of middle school, especially the odd behaviors that lurk in the shadows. Slip-on your lab coats, because we’re going to dissect these behaviors one by one to understand what’s really going on. With fun illustrations and choose-your-own-adventure-style scenarios, Middle School: Safety Goggles Advised will help you deal with the drama and define who you are and how to navigate life when things get, well, weird.

Dr Alan Grant is back to face a new generation of snarling, snapping dinosaurs in this fun activity book for fans of Jurassic World: Dominion. In a world where dinosaurs live among people, he'll need all of his expertise to survive. Build your Alan Grant LEGO (R) minifigure before reading the comics and completing the puzzles.Jurassic World Dominion (c) 2022 Universal City Studios LLC and Amblin Entertainment, Inc. All Rights Reserved. LEGO, the LEGO logo, the Brick and Knob configurations and the Minifigure are trademarks of the LEGO Group.(c)2022 The LEGO Group.

Have fun and discover letter shapes in this moving-counter play book!Toddlers can start their writing journey without having to grasp a pen ­- just slide the counters around each track and have fun with the rhyming text!This book features curved tracks that mimic early handwriting patterns and with Waves and Wiggles little ones can become familiar with letter shapes: W, M, N, U and V. The five sliding counters in this book have fingerholes to help keep little hands steady and the rhyming narrative and bright illustrations from Ekaterina Trukhan will keep them entertained as they whizz around the tracks!This Learn&Play title:Boosts motor skillsIntroduces letter shapesRecommended for children 2+Look out for the other Ladybird Learn&Play title:Swirls and Squiggles

Have fun and discover letter shapes in this moving-counter play book!Toddlers can start their writing journey without having to grasp a pen ­- just slide the counters around each track and have fun with the rhyming text!This book features curved tracks that mimic early handwriting patterns and with Swirls and Squiggles little ones can become familiar with letter shapes: S, C, Z, E and O. The five sliding counters in this book have fingerholes to help keep little hands steady and the rhyming narrative and bright illustrations from Ekaterina Trukhan will keep them entertained as they whizz around the tracks!This Learn&Play title:Boosts motor skillsIntroduces letter shapesRecommended for children 2+Look out for the other Ladybird Learn&Play title:Waves and Wiggles

'I want to be me! The glorious glittering me . . .People like me here Celestine! They adore me!'Victoria Stitch has escaped from the confines of Wiskling Wood and flown into the human world. Here, she breaks the most sacred of all wiskling laws and speaks to a human. Where she is feared and disgraced in Wiskling Wood, she is adored and revered in the human world.But the net is closing in. There are wisklings who would like to end Victoria Stitch's famous reign in the human world for good. Will her beloved twin, Celestine, be able to warn her in time? And even if she can, will Victoria Stitch listen?Review of Victoria Stitch: Bad and Glittering. This absorbing miniature melodrama is full of fraught sibling fondness between sweet, gentle Celestine and the marvellously ambitious and snooty Victoria, with Muncaster's own enticing illustrations. - The GuardianReview of Victoria Stitch: Bad and Glittering. Packed full of gothic glam and with a hefty dose of sparkles and glitter, Victoria Sti

The groundbreaking feminist and socialist writings of Puerto Rican author and activist Luisa Capetillo A Penguin Classic In 1915, Puerto Rican activist Luisa Capetillo was arrested and acquitted in 1915 for being the first woman to wear men's trousers publicly. While this act of gender-nonconforming rebellion elevated her to feminist icon status in modern pop culture, it also overshadowed the significant contributions she made to both the women's movement and anarchist labor movements of the early twentieth century--both in her native Puerto Rico and in the migrant labor belt in the eastern United States. With the volume A Nation of Women, Capetillo's socialist and feminist activism is given the spotlight it deserves with its inclusion of the first English translation of Capetillo's landmark Mi opini n sobre las libertades, derechos y deberes de la mujer. Originally published in Spanish in 1911, Mi opini n is considered by many to be the first feminist treatise in Puerto Rico and one o

With over 20 million copies sold in the US and Canada, and translated into more than 34 languages, Orson Scott Card's Ender series is one of Tor's all-time bestselling series, now repackaged for new r

It's play time! Can you play on the swings and jump on the trampoline?In this fun new series, little ones learn first words and experiences by using satisfying sliders and sturdy flaps. Each spread in

It's gardening time! Can you rake the soil and plant the seeds?In this fun new series, little ones learn first words and experiences by using satisfying sliders and sturdy flaps. Each spread introduce

What secrets are hidden within the walls of a desolate farmhouse in a forgotten corner of Lapland?Early spring has its icy grip on Odesmark, a small village in northernmost Sweden, abandoned by many o

The second book in the delightfully sweet Heartstopper series, featuring beautiful two-color artwork! "Absolutely delightful. Sweet, romantic, kind. Beautifully paced. I loved this book." -- Rainbow R

From the author of the #1 New York Times bestseller On Tyranny comes an impassioned condemnation of America’s coronavirus response and an urgent call to rethink health and freedom.On December 29, 2019